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DYSF dysferlin [ Talpa occidentalis (Iberian mole) ]

Gene ID: 119259057, updated on 21-Mar-2024

Summary

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Gene symbol
DYSF
Gene description
dysferlin
Gene type
protein coding
RefSeq status
MODEL
Organism
Talpa occidentalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Talpa
Orthologs
human mouse all
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Genomic context

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See DYSF in Genome Data Viewer
Location:
chromosome: Un
Exon count:
58
Annotation release Status Assembly Chr Location
RS_2023_03 current MPIMG_talOcc4v2.1 (GCF_014898055.3) Unplaced Scaffold NW_023604861.1 (82987288..83191541)

NW_023604861.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119259855 Neighboring gene zinc finger protein 638 Neighboring gene U4 spliceosomal RNA Neighboring gene ribosome biogenesis protein NSA2 homolog Neighboring gene uncharacterized LOC129146896 Neighboring gene cytochrome P450 26B1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_023604861 Unplaced Scaffold Reference MPIMG_talOcc4v2.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-tubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monocyte activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dysferlin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_014898055.3-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference MPIMG_talOcc4v2.1 Primary Assembly

Genomic

  1. NW_023604861.1 Reference MPIMG_talOcc4v2.1 Primary Assembly

    Range
    82987288..83191541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037527596.2 → XP_037383493.1  dysferlin isoform X1

    Conserved Domains (11) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1632 → 1755
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1866 → 1997
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:2010 → 2097
    Ferlin_C; Ferlin C-terminus

  2. XM_037527598.2 → XP_037383495.1  dysferlin isoform X3

    Conserved Domains (11) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1618 → 1741
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1852 → 1983
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1996 → 2083
    Ferlin_C; Ferlin C-terminus

  3. XM_037527600.2 → XP_037383497.1  dysferlin isoform X5

    Conserved Domains (11) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1597 → 1720
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1831 → 1962
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1975 → 2062
    Ferlin_C; Ferlin C-terminus

  4. XM_037527602.2 → XP_037383499.1  dysferlin isoform X7

    Conserved Domains (11) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1139 → 1267
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1587 → 1710
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1821 → 1952
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:933 → 989
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:773 → 846
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 742
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1965 → 2052
    Ferlin_C; Ferlin C-terminus

  5. XM_037527604.2 → XP_037383501.1  dysferlin isoform X9

    Conserved Domains (11) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1139 → 1267
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1566 → 1689
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1800 → 1931
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:933 → 989
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:773 → 846
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 742
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1944 → 2031
    Ferlin_C; Ferlin C-terminus

  6. XM_037527597.2 → XP_037383494.1  dysferlin isoform X2

    Conserved Domains (11) summary
    cd04011
    Location:250 → 359
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1171 → 1299
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:413 → 573
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1619 → 1742
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1853 → 1984
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:965 → 1021
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:805 → 878
    FerB; FerB (NUC096) domain
    pfam08151
    Location:357 → 407
    FerI; FerI (NUC094) domain
    pfam08165
    Location:717 → 774
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1997 → 2084
    Ferlin_C; Ferlin C-terminus

  7. XM_037527599.2 → XP_037383496.1  dysferlin isoform X4

    Conserved Domains (11) summary
    cd04011
    Location:250 → 359
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1171 → 1299
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:413 → 573
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1598 → 1721
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1832 → 1963
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:965 → 1021
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:805 → 878
    FerB; FerB (NUC096) domain
    pfam08151
    Location:357 → 407
    FerI; FerI (NUC094) domain
    pfam08165
    Location:717 → 774
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1976 → 2063
    Ferlin_C; Ferlin C-terminus

  8. XM_037527601.2 → XP_037383498.1  dysferlin isoform X6

    Conserved Domains (11) summary
    cd04011
    Location:219 → 328
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1140 → 1268
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:382 → 542
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1588 → 1711
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1822 → 1953
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:934 → 990
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:774 → 847
    FerB; FerB (NUC096) domain
    pfam08151
    Location:326 → 376
    FerI; FerI (NUC094) domain
    pfam08165
    Location:686 → 743
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1966 → 2053
    Ferlin_C; Ferlin C-terminus

  9. XM_037527603.2 → XP_037383500.1  dysferlin isoform X8

    Conserved Domains (11) summary
    cd04011
    Location:219 → 328
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1140 → 1268
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:382 → 542
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1567 → 1690
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 136
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1801 → 1932
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:934 → 990
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:774 → 847
    FerB; FerB (NUC096) domain
    pfam08151
    Location:326 → 376
    FerI; FerI (NUC094) domain
    pfam08165
    Location:686 → 743
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1945 → 2032
    Ferlin_C; Ferlin C-terminus
Nucleotide Protein
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