Atf2 activating transcription factor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atf2provided by MGI
Official Full Name: activating transcription factor 2provided by MGI
Primary source: MGI:MGI:109349
See related: Ensembl:ENSMUSG00000027104 AllianceGenome:MGI:109349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mXBP; Atf-2; Creb2; CRE-BP; D130078H02Rik; Tg(Gzma-Klra1)7Wum
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and protein dimerization activity. Involved in several processes, including growth plate cartilage development; hindbrain development; and intracellular signal transduction. Acts upstream of or within with a positive effect on cellular response to leucine starvation and regulation of transcription by RNA polymerase II. Acts upstream of or within adipose tissue development; outflow tract morphogenesis; and positive regulation of transforming growth factor beta2 production. Located in membrane; nucleus; and site of double-strand break. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study meconium aspiration syndrome and osteochondrodysplasia. Orthologous to human ATF2 (activating transcription factor 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E14 (RPKM 7.9), frontal lobe adult (RPKM 7.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C3; 2 43.86 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (73646853..73723094, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (73816509..73892677, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The P38MAPK/ATF2 signaling pathway is involved in PND in mice.
Title: The P38MAPK/ATF2 signaling pathway is involved in PND in mice.
Phosphorylation of ATF2 promotes odontoblastic differentiation via intrinsic HAT activity.
Title: Phosphorylation of ATF2 promotes odontoblastic differentiation via intrinsic HAT activity.
lncRNA PINK1-AS Aggravates Cerebral Ischemia/Reperfusion Oxidative Stress Injury through Regulating ATF2 by Sponging miR-203.
Title: lncRNA PINK1-AS Aggravates Cerebral Ischemia/Reperfusion Oxidative Stress Injury through Regulating ATF2 by Sponging miR-203.
Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
Title: Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
Title: ATF2 and ATF7 Are Critical Mediators of Intestinal Epithelial Repair.
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
Title: The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.
the expression and biological function of ATF2 in CNS inflammation
Title: TRAF6-p38/JNK-ATF2 axis promotes microglial inflammatory activation.
Phosphorylation of ATF2 at Thr-52 was reduced in the hippocampus of PKCepsilon null mice, suggesting that ATF2 is a phosphorylation substrate of PKCepsilon. PKCepsilon protein concentrations were significantly reduced 4, 24, 48 and 72 h after transient global cerebral ischemia, resulting in translocation of nuclear ATF2 to the mitochondria. Degenerating neurons staining positively with Fluoro-Jade C exhibited cytoplasm...
Title: PKCε phosphorylation regulates the mitochondrial translocation of ATF2 in ischemia-induced neurodegeneration.
The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429(Deltahep)), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of ...
Title: Dual regulation of HMGB1 by combined JNK1/2-ATF2 axis with miR-200 family in nonalcoholic steatohepatitis in mice.
These findings point to an oncogenic function for ATF2 in melanoma development that appears to be independent of its transcriptional activity.
Title: A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (7) 1 citation
Transgenic (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-33561 (e-PCR)
- UniSTS:4379

Atf2 (e-PCR), detects polymorphism
- UniSTS:515957

RH142313 (e-PCR)
- UniSTS:231560

D18875 (e-PCR)
- UniSTS:158974

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP response element binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP response element binding	ISO Inferred from Sequence Orthology more info
enables cAMP response element binding protein binding	IEA Inferred from Electronic Annotation more info
enables cAMP response element binding protein binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone H2B acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H2B acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H4 acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables leucine zipper domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in NK T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in abducens nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adipose tissue development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in amelogenesis	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process involved in development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brainstem development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to anisomycin	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to anisomycin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect cellular response to leucine starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of cell density	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in facial nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth plate cartilage chondrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in growth plate cartilage chondrocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hepatocyte apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hypoglossal nucleus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in motor neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neurofilament cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in p38MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in p38MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cardiac muscle myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cardiac muscle myoblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane permeability involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within_positive_effect positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transforming growth factor beta2 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle checkpoint	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within_positive_effect regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in response to osmotic stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription initiation-coupled chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in vacuole organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within white fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in white fat cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CCAAT-binding factor complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of H4 histone acetyltransferase complex	IEA Inferred from Electronic Annotation more info
part_of H4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in site of double-strand break	IMP Inferred from Mutant Phenotype more info	PubMed
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclic AMP-dependent transcription factor ATF-2

Names: cAMP response element-binding protein CRE-BP1; cAMP-dependent transcription factor ATF-2

NP_001020264.1

EC 2.3.1.48

NP_001271298.1

EC 2.3.1.48

NP_001271299.1

EC 2.3.1.48

NP_001271300.1

EC 2.3.1.48

NP_001271301.1

EC 2.3.1.48

NP_001271302.1

EC 2.3.1.48

NP_001271303.1

EC 2.3.1.48

NP_001271305.1

EC 2.3.1.48

NP_033845.1

EC 2.3.1.48

XP_030102700.1

EC 2.3.1.48

XP_030102701.1

EC 2.3.1.48

XP_030102703.1

EC 2.3.1.48

XP_030102704.1

EC 2.3.1.48

XP_030102706.1

EC 2.3.1.48

XP_030102707.1

EC 2.3.1.48

XP_030102710.1

EC 2.3.1.48

XP_030102713.1

EC 2.3.1.48

XP_030102715.1

EC 2.3.1.48

XP_030102718.1

EC 2.3.1.48

XP_030102727.1

EC 2.3.1.48

XP_030102732.1

EC 2.3.1.48

XP_030102733.1

EC 2.3.1.48

XP_036013584.1

EC 2.3.1.48

XP_036013587.1

EC 2.3.1.48

XP_036013593.1

EC 2.3.1.48

XP_036013600.1

EC 2.3.1.48

XP_036013601.1

EC 2.3.1.48

XP_036013602.1

EC 2.3.1.48

XP_036013604.1

EC 2.3.1.48

XP_036013605.1

EC 2.3.1.48

XP_036013606.1

EC 2.3.1.48

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025093.2 → NP_001020264.1 cyclic AMP-dependent transcription factor ATF-2 isoform 1

See identical proteins and their annotated locations for NP_001020264.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).

Source sequence(s)

AK051591, AL844581, AL845523, BC079883, BC082596

Consensus CDS

CCDS16134.1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001284369.1 → NP_001271298.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2

See identical proteins and their annotated locations for NP_001271298.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1. Variants 2 and 3 encode the same protein.

Source sequence(s)

AK035438, AK139515, AL844581, AL845523

Consensus CDS

CCDS16135.1

UniProtKB/TrEMBL

Q543G2, Q68FE3

Related

ENSMUSP00000107641.3, ENSMUST00000112010.9

Conserved Domains (3) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:144 → 272

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
NM_001284370.1 → NP_001271299.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4

See identical proteins and their annotated locations for NP_001271299.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks an exon and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.

Source sequence(s)

AK035438, AK146839, AL844581, BY474294

UniProtKB/TrEMBL

G3UXC3, Q8CBR9

Related

ENSMUST00000143714.8

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:336 → 377

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001284371.1 → NP_001271300.1 cyclic AMP-dependent transcription factor ATF-2 isoform 4

See identical proteins and their annotated locations for NP_001271300.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, lacks an exon, and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1. Variants 5 and 6 encode the same protein.

Source sequence(s)

AK035438, AK146839, AL844581, BY474294

UniProtKB/TrEMBL

G3UXC3, Q8CBR9

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:336 → 377

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001284372.1 → NP_001271301.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5

See identical proteins and their annotated locations for NP_001271301.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.

Source sequence(s)

AL844581, AL845523

Consensus CDS

CCDS71076.1

UniProtKB/TrEMBL

Q640L6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001284373.1 → NP_001271302.1 cyclic AMP-dependent transcription factor ATF-2 isoform 5

See identical proteins and their annotated locations for NP_001271302.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and lacks two alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.

Source sequence(s)

AL844581, BC079883, BC082596

Consensus CDS

CCDS71076.1

UniProtKB/TrEMBL

Q640L6

Related

ENSMUSP00000107647.3, ENSMUST00000112016.9

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
NM_001284374.1 → NP_001271303.1 cyclic AMP-dependent transcription factor ATF-2 isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (9) differs in the 5' UTR and lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG. The resulting protein (isoform 6) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AL844581, AL845523, BC082596, BC085137

UniProtKB/TrEMBL

P70299

Related

ENSMUST00000156455.8

Conserved Domains (1) summary

cd14687
Location:101 → 161

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
NM_001284376.1 → NP_001271305.1 cyclic AMP-dependent transcription factor ATF-2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon, contains an alternate in-frame exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.

Source sequence(s)

AL844581, AL845523, BC079883, BC082596

UniProtKB/TrEMBL

Q68FE3

Conserved Domains (2) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:289 → 349

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
NM_009715.3 → NP_033845.1 cyclic AMP-dependent transcription factor ATF-2 isoform 2

See identical proteins and their annotated locations for NP_033845.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.. Variants 2 and 3 encode the same protein.

Source sequence(s)

AK051591, AL844581, AL845523, BC079883

Consensus CDS

CCDS16135.1

UniProtKB/TrEMBL

Q543G2, Q68FE3

Related

ENSMUSP00000107638.2, ENSMUST00000112007.8

Conserved Domains (3) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:144 → 272

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

73646853..73723094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246850.2 → XP_030102710.1 cyclic AMP-dependent transcription factor ATF-2 isoform X3

UniProtKB/TrEMBL

G3UXC3

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:336 → 382

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05109
Location:72 → 331

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_030246847.2 → XP_030102707.1 cyclic AMP-dependent transcription factor ATF-2 isoform X3

UniProtKB/TrEMBL

G3UXC3

Related

ENSMUSP00000133632.2, ENSMUST00000173010.8

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:336 → 382

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam05109
Location:72 → 331

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_030246840.2 → XP_030102700.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Related

ENSMUSP00000107648.2, ENSMUST00000112017.8

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246846.2 → XP_030102706.1 cyclic AMP-dependent transcription factor ATF-2 isoform X2

UniProtKB/TrEMBL

Q543G2, Q68FE3

Related

ENSMUSP00000088311.5, ENSMUST00000090802.11

Conserved Domains (3) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:144 → 272

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_036157694.1 → XP_036013587.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246872.1 → XP_030102732.1 cyclic AMP-dependent transcription factor ATF-2 isoform X6

Conserved Domains (2) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:198 → 258

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_030246855.1 → XP_030102715.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4

UniProtKB/TrEMBL

Q640L6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246858.1 → XP_030102718.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4

UniProtKB/TrEMBL

Q640L6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036157708.1 → XP_036013601.1 cyclic AMP-dependent transcription factor ATF-2 isoform X2

UniProtKB/TrEMBL

Q543G2, Q68FE3

Conserved Domains (3) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:144 → 272

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_030246843.2 → XP_030102703.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246873.1 → XP_030102733.1 cyclic AMP-dependent transcription factor ATF-2 isoform X7

Conserved Domains (2) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 284

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_036157711.1 → XP_036013604.1 cyclic AMP-dependent transcription factor ATF-2 isoform X5

Conserved Domains (2) summary

cd12192
Location:15 → 52

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:206 → 266

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_036157707.1 → XP_036013600.1 cyclic AMP-dependent transcription factor ATF-2 isoform X2

UniProtKB/TrEMBL

Q543G2, Q68FE3

Conserved Domains (3) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:144 → 272

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:296 → 356

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_036157712.1 → XP_036013605.1 cyclic AMP-dependent transcription factor ATF-2 isoform X6

Conserved Domains (2) summary

cd12192
Location:9 → 44

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:198 → 258

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
XM_036157709.1 → XP_036013602.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4

UniProtKB/TrEMBL

Q640L6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036157691.1 → XP_036013584.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Related

ENSMUSP00000097588.5, ENSMUST00000100009.11

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246844.2 → XP_030102704.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246853.2 → XP_030102713.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4

UniProtKB/TrEMBL

Q640L6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246841.2 → XP_030102701.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_030246867.1 → XP_030102727.1 cyclic AMP-dependent transcription factor ATF-2 isoform X4

UniProtKB/TrEMBL

Q640L6

Conserved Domains (3) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

cd14687
Location:238 → 298

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036157700.1 → XP_036013593.1 cyclic AMP-dependent transcription factor ATF-2 isoform X1

UniProtKB/Swiss-Prot

P16951, Q64089, Q64090, Q64091

UniProtKB/TrEMBL

Q8CGB4

Conserved Domains (4) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

PRK14951
Location:184 → 312

PRK14951; DNA polymerase III subunits gamma and tau; Provisional

cd14687
Location:336 → 396

bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_036157713.1 → XP_036013606.1 cyclic AMP-dependent transcription factor ATF-2 isoform X8

UniProtKB/TrEMBL

A2AQF0

Related

ENSMUSP00000118560.2, ENSMUST00000128531.8

Conserved Domains (2) summary

cd12192
Location:47 → 84

GCN4_cent; GCN4 central activation domain-like acidic activation domain

sd00019
Location:9 → 31

ZF_C2H2; C2H2 Zn finger [structural motif]