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dysf dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive) [ Acanthopagrus latus (yellowfin seabream) ]

Gene ID: 119026986, updated on 21-Mar-2024

Summary

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Gene symbol
dysf
Gene description
dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)
See related
EnsemblRapid:ENSALTG00010013414
Gene type
protein coding
RefSeq status
MODEL
Organism
Acanthopagrus latus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Spariformes; Sparidae; Acanthopagrus
Orthologs
human zebrafish all
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Genomic context

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See dysf in Genome Data Viewer
Location:
chromosome: 10
Exon count:
59
Annotation release Status Assembly Chr Location
100 current fAcaLat1.1 (GCF_904848185.1) 10 NC_051048.1 (3502188..3574040)

Chromosome 10 - NC_051048.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119026984 Neighboring gene uncharacterized LOC119026983 Neighboring gene type-2 ice-structuring protein-like Neighboring gene uncharacterized LOC119027048 Neighboring gene uncharacterized LOC119027049 Neighboring gene uncharacterized LOC119027045 Neighboring gene uncharacterized LOC119027043 Neighboring gene uncharacterized LOC119026992

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_051048.1 Chromosome 10 Reference fAcaLat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-tubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monocyte activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dysferlin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Acanthopagrus latus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fAcaLat1.1 Primary Assembly

Genomic

  1. NC_051048.1 Reference fAcaLat1.1 Primary Assembly

    Range
    3502188..3574040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037111749.1 → XP_036967644.1  dysferlin isoform X2

    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1163 → 1287
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1631 → 1754
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1865 → 1996
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:890 → 948
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 874
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:2007 → 2118
    Ferlin_C; Ferlin C-terminus

  2. XM_037111748.1 → XP_036967643.1  dysferlin isoform X1

    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1164 → 1288
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1632 → 1755
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1866 → 1997
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:890 → 948
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 874
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:2008 → 2119
    Ferlin_C; Ferlin C-terminus

  3. XM_037111750.1 → XP_036967645.1  dysferlin isoform X3

    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1164 → 1288
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1628 → 1751
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1862 → 1993
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:890 → 948
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 874
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:2004 → 2115
    Ferlin_C; Ferlin C-terminus

  4. XM_037111753.1 → XP_036967648.1  dysferlin isoform X6

    Related
    ENSALTP00010035808.1, ENSALTT00010038579.1
    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1164 → 1288
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1608 → 1731
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1842 → 1973
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:890 → 948
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 874
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1984 → 2095
    Ferlin_C; Ferlin C-terminus

  5. XM_037111752.1 → XP_036967647.1  dysferlin isoform X5

    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1277
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 560
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1621 → 1744
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1855 → 1986
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:879 → 937
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:793 → 863
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:704 → 761
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1997 → 2108
    Ferlin_C; Ferlin C-terminus

  6. XM_037111757.1 → XP_036967652.1  dysferlin isoform X9

    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1277
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 560
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1617 → 1740
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1851 → 1982
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:879 → 937
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:793 → 863
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:704 → 761
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1993 → 2104
    Ferlin_C; Ferlin C-terminus

  7. XM_037111759.1 → XP_036967654.1  dysferlin isoform X11

    Related
    ENSALTP00010035814.1, ENSALTT00010038585.1
    Conserved Domains (11) summary
    cd04011
    Location:237 → 346
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1277
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:400 → 560
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1597 → 1720
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 135
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1831 → 1962
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:879 → 937
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:793 → 863
    FerB; FerB (NUC096) domain
    pfam08151
    Location:345 → 394
    FerI; FerI (NUC094) domain
    pfam08165
    Location:704 → 761
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1973 → 2084
    Ferlin_C; Ferlin C-terminus

  8. XM_037111751.1 → XP_036967646.1  dysferlin isoform X4

    Conserved Domains (11) summary
    cd04011
    Location:232 → 341
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1159 → 1283
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:395 → 566
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1627 → 1750
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:10 → 130
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1861 → 1992
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:885 → 943
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:799 → 869
    FerB; FerB (NUC096) domain
    pfam08151
    Location:340 → 389
    FerI; FerI (NUC094) domain
    pfam08165
    Location:710 → 767
    FerA; FerA (NUC095) domain
    pfam16165
    Location:2003 → 2114
    Ferlin_C; Ferlin C-terminus

  9. XM_037111754.1 → XP_036967649.1  dysferlin isoform X7

    Conserved Domains (11) summary
    cd04011
    Location:232 → 341
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1159 → 1283
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:395 → 566
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1623 → 1746
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:10 → 130
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1857 → 1988
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:885 → 943
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:799 → 869
    FerB; FerB (NUC096) domain
    pfam08151
    Location:340 → 389
    FerI; FerI (NUC094) domain
    pfam08165
    Location:710 → 767
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1999 → 2110
    Ferlin_C; Ferlin C-terminus

  10. XM_037111758.1 → XP_036967653.1  dysferlin isoform X10

    Related
    ENSALTP00010035750.1, ENSALTT00010038521.1
    Conserved Domains (11) summary
    cd04011
    Location:232 → 341
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1148 → 1272
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:395 → 555
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1612 → 1735
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:10 → 130
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1846 → 1977
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:874 → 932
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:788 → 858
    FerB; FerB (NUC096) domain
    pfam08151
    Location:340 → 389
    FerI; FerI (NUC094) domain
    pfam08165
    Location:699 → 756
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1988 → 2099
    Ferlin_C; Ferlin C-terminus

  11. XM_037111755.1 → XP_036967650.1  dysferlin isoform X8

    Conserved Domains (11) summary
    cd04011
    Location:232 → 341
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1148 → 1272
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:395 → 555
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1592 → 1715
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:10 → 130
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1826 → 1957
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:874 → 932
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:788 → 858
    FerB; FerB (NUC096) domain
    pfam08151
    Location:340 → 389
    FerI; FerI (NUC094) domain
    pfam08165
    Location:699 → 756
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1968 → 2079
    Ferlin_C; Ferlin C-terminus
Nucleotide Protein
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