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F12 coagulation factor XII [ Balaenoptera musculus (blue whale) ]

Gene ID: 118892560, updated on 20-Mar-2024

Summary

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Gene symbol
F12
Gene description
coagulation factor XII
Gene type
protein coding
RefSeq status
MODEL
Organism
Balaenoptera musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Mysticeti; Balaenopteridae; Balaenoptera
Orthologs
human mouse all
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Genomic context

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See F12 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
14
Annotation release Status Assembly Chr Location
100 current mBalMus1.pri.v3 (GCF_009873245.2) 3 NC_045787.1 (150667882..150680912, complement)

Chromosome 3 - NC_045787.1Genomic Context describing neighboring genes Neighboring gene mediator of RNA polymerase II transcription subunit 28-like Neighboring gene profilin 3 Neighboring gene elongation factor 1-alpha 1-like Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene proline rich 7, synaptic

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045787.1 Chromosome 3 Reference mBalMus1.pri.v3 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
LOW QUALITY PROTEIN: coagulation factor XII

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Balaenoptera musculus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mBalMus1.pri.v3 Primary Assembly

Genomic

  1. NC_045787.1 Reference mBalMus1.pri.v3 Primary Assembly

    Range
    150667882..150680912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036847311.1 → XP_036703206.1  LOW QUALITY PROTEIN: coagulation factor XII

    UniProtKB/TrEMBL
    A0A8B8X138
    Conserved Domains (6) summary
    smart00059
    Location:45 → 94
    FN2; Fibronectin type 2 domain
    smart00020
    Location:384 → 622
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:102 → 137
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:139 → 179
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    pfam00008
    Location:184 → 213
    EGF; EGF-like domain
    cl00100
    Location:223 → 303
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
Nucleotide Protein
Heading Accession and Version

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