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Synpo2 synaptopodin 2 [ Mus musculus (house mouse) ]

Gene ID: 118449, updated on 12-May-2024

Summary

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Official Symbol
Synpo2provided by MGI
Official Full Name
synaptopodin 2provided by MGI
Primary source
MGI:MGI:2153070
See related
Ensembl:ENSMUSG00000050315 AllianceGenome:MGI:2153070
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myo; 1110069I04Rik; 2310068J10Rik; 9530006G20Rik
Summary
Enables 14-3-3 protein binding activity and muscle alpha-actinin binding activity. Predicted to be involved in several processes, including chaperone-mediated autophagy; positive regulation of actin filament bundle assembly; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in nucleus. Is expressed in urinary system. Orthologous to human SYNPO2 (synaptopodin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 58.2), subcutaneous fat pad adult (RPKM 12.4) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Synpo2 in Genome Data Viewer
Location:
3 G1; 3 53.8 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (122870168..123029817, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (123076519..123236168, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08897 Neighboring gene STARR-positive B cell enhancer ABC_E6116 Neighboring gene STARR-seq mESC enhancer starr_08899 Neighboring gene ubiquitin specific peptidase 53 Neighboring gene myozenin 2 Neighboring gene STARR-seq mESC enhancer starr_08901 Neighboring gene predicted gene, 54182 Neighboring gene STARR-seq mESC enhancer starr_08902 Neighboring gene STARR-positive B cell enhancer ABC_E10211 Neighboring gene STARR-seq mESC enhancer starr_08903 Neighboring gene STARR-seq mESC enhancer starr_08904 Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene STARR-positive B cell enhancer mm9_chr3:123076377-123076678 Neighboring gene STARR-positive B cell enhancer mm9_chr3:123088670-123088971 Neighboring gene methyltransferase 14, N6-adenosine-methyltransferase subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of smooth muscle dystrophin and synaptopodin 2 expression by actin polymerization and vascular injury. Turczyńska KM, et al. Arterioscler Thromb Vasc Biol, 2015 Jun. PMID 25857312
  2. Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress. Lohanadan K, et al. Exp Cell Res, 2021 Nov 15. PMID 34637763
  3. Promotion of importin alpha-mediated nuclear import by the phosphorylation-dependent binding of cargo protein to 14-3-3. Faul C, et al. J Cell Biol, 2005 May 9. PMID 15883195, Free PMC Article
  4. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. Weins A, et al. J Cell Biol, 2001 Oct 29. PMID 11673475, Free PMC Article
  5. Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes. Faul C, et al. Mol Cell Biol, 2007 Dec. PMID 17923693, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.
    Title: Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.
  2. The identification of myopodin as a direct target of PKA, CaMKII, and calcineurin defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart.
    Title: Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC189849

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables alpha-actinin binding ISO
Inferred from Sequence Orthology
more info
  
enables filamin binding ISO
Inferred from Sequence Orthology
more info
  
enables muscle alpha-actinin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in chaperone-mediated autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of actin filament bundle assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Rho-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  
part_of vesicle tethering complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
synaptopodin-2
Names
myopodin
mypodin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388502.1 → NP_001375431.1  synaptopodin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121315, AC121540
    UniProtKB/Swiss-Prot
    Q8C592, Q91YE8
    UniProtKB/TrEMBL
    B2RY03
    Related
    ENSMUSP00000142508.2, ENSMUST00000198584.2
    Conserved Domains (2) summary
    PHA03247
    Location:571 → 1073
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

  2. NM_001389265.1 → NP_001376194.1  synaptopodin-2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC121540
    Conserved Domains (1) summary
    PHA03247
    Location:186 → 688
    PHA03247; large tegument protein UL36; Provisional

  3. NM_001389266.1 → NP_001376195.1  synaptopodin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC121540
    UniProtKB/TrEMBL
    A0A498WGE8
    Related
    ENSMUSP00000051570.8, ENSMUST00000051443.8
    Conserved Domains (1) summary
    PHA03247
    Location:186 → 688
    PHA03247; large tegument protein UL36; Provisional

  4. NM_080451.2 → NP_536699.2  synaptopodin-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121315, AC121540
    Consensus CDS
    CCDS51063.1
    UniProtKB/TrEMBL
    B2RY03, E9Q1U2
    Related
    ENSMUSP00000102034.2, ENSMUST00000106426.8
    Conserved Domains (1) summary
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    122870168..123029817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500925.4 → XP_006500988.1  synaptopodin-2 isoform X1

    UniProtKB/TrEMBL
    B2RY03
    Conserved Domains (2) summary
    PHA03247
    Location:571 → 1073
    PHA03247; large tegument protein UL36; Provisional
    cd00992
    Location:7 → 85
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YE8.2 GenPept UniProtKB/Swiss-Prot:Q91YE8

Gene LinkOut

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