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These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in Genomic regions,
transcripts, and products above.
mRNA and Protein(s)
-
NM_001308641.1 → NP_001295570.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295570.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as a/1) contains an alternate 5' terminal exon, which causes translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23A) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000159185.2, ENSMUST00000238946.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001308642.1 → NP_001295571.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295571.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (4, also known as ad/1) contains alternate exons at the 5' end, which cause translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23A) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000157337.2, ENSMUST00000234053.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001308643.1 → NP_001295572.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295572.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (5, also known as ab/1) contains alternate exons at the 5' end, which cause translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23A) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000157152.2, ENSMUST00000234473.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001308644.1 → NP_001295573.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295573.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (6, also known as ac/1) contains alternate exons at the 5' end, which cause translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23A) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000157239.2, ENSMUST00000234518.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001308645.1 → NP_001295574.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295574.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (7, also known as abc/1) contains alternate exons at the 5' end, which cause translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23A) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000157347.2, ENSMUST00000234391.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001308646.1 → NP_001295575.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295575.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (8, also known as abcd/1) contains alternate exons at the 5' end, which cause translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23A) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000157000.2, ENSMUST00000235044.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001308647.2 → NP_001295576.1 aquaporin-4 isoform M23
See identical proteins and their annotated locations for NP_001295576.1
Status: REVIEWED
- Description
- Transcript Variant: This variant (2, also known as AQP4.M23X or mMIWC1) contains an alternate 5' terminal exon, which causes translation initiation from an in-frame, downstream start codon, compared to variant 1. The resulting isoform (M23, also known as M23X) has a shorter N-terminus compared to isoform 1. Variants 2-8 encode the same isoform.
- Source sequence(s)
-
AC133525, AF469169, AK045357, AK079614, BB750519, BX633380, U88623
- Consensus CDS
-
CCDS89196.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
Q50H70
- Related
- ENSMUSP00000157060.2, ENSMUST00000234643.2
- Conserved Domains (1) summary
-
- pfam00230
Location:9 → 226
- MIP; Major intrinsic protein
-
NM_001317729.1 → NP_001304658.1 aquaporin-4 isoform M1x
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as AQP4.M1 or mMIWC2) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (M1) results from translation termination at the upstream UGA stop codon, while the longer isoform (M1x) results from UGA stop codon readthrough to the downstream UAA termination codon. This RefSeq represents the longer, C-terminally extended isoform (M1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
- Source sequence(s)
-
AC133525, AF469168, AK045357, AK079614, BB750519, BX633380, U88623
- UniProtKB/TrEMBL
-
A0A5F8MQ17
- Conserved Domains (1) summary
-
- pfam00230
Location:31 → 248
- MIP; Major intrinsic protein
-
NM_009700.3 → NP_033830.2 aquaporin-4 isoform M1
See identical proteins and their annotated locations for NP_033830.2
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as AQP4.M1 or mMIWC2) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (M1) results from translation termination at the upstream UGA stop codon, while the longer isoform (M1x) results from UGA stop codon readthrough to the downstream UAA termination codon. This RefSeq represents the shorter isoform (M1).
- Source sequence(s)
-
AC133525, AF469168, AK045357, AK079614, BB750519, BX633380, U88623
- Consensus CDS
-
CCDS29073.1
- UniProtKB/Swiss-Prot
- P55088, P97818, Q4FJP1, Q61131, Q61132, Q8VHE4, Q8VHE5, Q9EQI3
- UniProtKB/TrEMBL
-
A0A0R4J0Z3
- Related
- ENSMUSP00000078088.7, ENSMUST00000079081.8
- Conserved Domains (1) summary
-
- pfam00230
Location:31 → 248
- MIP; Major intrinsic protein
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as
RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate
assemblies. Model RNAs and proteins are also reported here.
Reference GRCm39 C57BL/6J
Genomic
-
NC_000084.7 Reference GRCm39 C57BL/6J
- Range
-
15522451..15544039 complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)