Aqp3 aquaporin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aqp3provided by MGI
Official Full Name: aquaporin 3provided by MGI
Primary source: MGI:MGI:1333777
See related: Ensembl:ENSMUSG00000028435 AllianceGenome:MGI:1333777
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AQP-2
Summary: Predicted to enable channel activity; identical protein binding activity; and urea transmembrane transporter activity. Involved in glycerol transmembrane transport and water transport. Acts upstream of or within several processes, including renal water absorption; response to ischemia; and urea transport. Located in basolateral plasma membrane and cell-cell junction. Is expressed in several structures, including alimentary system; capillary; early conceptus; genitourinary system; and sensory organ. Used to study nephrogenic diabetes insipidus. Orthologous to human AQP3 (aquaporin 3 (Gill blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 172.0), stomach adult (RPKM 137.4) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 20.94 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (41092724..41098183, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (41092724..41098183, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Verification of the gene and protein expression of the aquaglyceroporin AQP3 in the mammalian lens.
Title: Verification of the gene and protein expression of the aquaglyceroporin AQP3 in the mammalian lens.
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
Title: Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells.
Title: AQP3-mediated activation of the AMPK/SIRT1 signaling pathway curtails gallstone formation in mice by inhibiting inflammatory injury of gallbladder mucosal epithelial cells.
Advanced Glycation End Products and Activation of Toll-like Receptor-2 and -4 Induced Changes in Aquaporin-3 Expression in Mouse Keratinocytes.
Title: Advanced Glycation End Products and Activation of Toll-like Receptor-2 and -4 Induced Changes in Aquaporin-3 Expression in Mouse Keratinocytes.
Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development.
Title: Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development.
Distinct expression patterns of aquaporin 3 and 5 in ductal and alveolar epithelial cells in mouse mammary glands before and after parturition.
Title: Distinct expression patterns of aquaporin 3 and 5 in ductal and alveolar epithelial cells in mouse mammary glands before and after parturition.
Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation.
Title: Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation.
Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.
Title: Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.
AQP3 deletion slows cyst enlargement Pkd1 model of autosomal dominant polycystic kidney disease.
Title: Aquaporin-3 deficiency slows cyst enlargement in experimental mouse models of autosomal dominant polycystic kidney disease.
The expression levels of AQP3 and occludin were downregulated after septic intestinal injury, while treatment with glycerol, which acts as a substitute for AQP3, partly ameliorated intestinal injury and improved the survival rate. This preliminary experiment suggests that AQP3 may protect the intestinal tract against the effects of sepsis.
Title: Role of Aquaporin-3 in Intestinal Injury Induced by Sepsis.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (5) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_26051-26052:1032543524:1 (e-PCR)
- UniSTS:268923

Aqp3 (e-PCR), detects polymorphism
- UniSTS:186492

Aqp3 (e-PCR), detects polymorphism
- UniSTS:209564

Aqp3 (e-PCR), detects polymorphism
- UniSTS:530942

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glycerol channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol channel activity	ISO Inferred from Sequence Orthology more info
enables glycerol channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables polyol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables polyol transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables urea transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables water channel activity	ISO Inferred from Sequence Orthology more info
enables water channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables water channel activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycerol transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycerol transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in glycerol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in polyol transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immune system process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immune system process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal water absorption	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within renal water absorption	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to ischemia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to retinoic acid	IEA Inferred from Electronic Annotation more info
involved_in response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urea transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in water transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within water transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in water transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within water transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: aquaporin-3

Names: AQP-3; aquaglyceroporin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016689.2 → NP_057898.2 aquaporin-3

See identical proteins and their annotated locations for NP_057898.2

Status: VALIDATED

Source sequence(s)

AK145678

Consensus CDS

CCDS38714.1

UniProtKB/Swiss-Prot

Q3TU75, Q8R2N1, Q9JJN8, Q9WTJ3

Related

ENSMUSP00000055110.8, ENSMUST00000055327.8

Conserved Domains (1) summary

cd00333
Location:23 → 264

MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...