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NOTCH2 notch receptor 2 [ Mirounga leonina (Southern elephant seal) ]

Gene ID: 118000453, updated on 20-Mar-2024

Summary

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Gene symbol
NOTCH2
Gene description
notch receptor 2
Locus tag
GH733_018398
See related
EnsemblRapid:ENSMLOG00005017284
Gene type
protein coding
RefSeq status
MODEL
Organism
Mirounga leonina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Phocidae; Mirounga
Orthologs
human mouse all
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Genomic context

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See NOTCH2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
35
Annotation release Status Assembly Chr Location
100 current KU_Mleo_1.0 (GCF_011800145.1) Unplaced Scaffold NW_023270789.1 (347584..519214)

NW_023270789.1Genomic Context describing neighboring genes Neighboring gene SEC22 homolog B, vesicle trafficking protein Neighboring gene uncharacterized LOC118000452 Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene ADAM metallopeptidase domain 30 Neighboring gene regenerating family member 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_023270789 Unplaced Scaffold Reference KU_Mleo_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to tumor cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mirounga leonina Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference KU_Mleo_1.0 Primary Assembly

Genomic

  1. NW_023270789.1 Reference KU_Mleo_1.0 Primary Assembly

    Range
    347584..519214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034990168.1 → XP_034846059.1  neurogenic locus notch homolog protein 2 isoform X1

    Related
    ENSMLOP00005025139.1, ENSMLOT00005028312.1
    Conserved Domains (12) summary
    smart00004
    Location:1421 → 1455
    NL; Domain found in Notch and Lin-12
    PHA03247
    Location:2068 → 2413
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1879 → 2066
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182 → 218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1943 → 1974
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1505 → 1534
    Notch; LNR domain
    pfam03154
    Location:2273 → 2467
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1540 → 1594
    NOD; NOTCH protein
    pfam07684
    Location:1619 → 1674
    NODP; NOTCH protein
    pfam11936
    Location:2381 → 2444
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1948 → 2040
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1659 → 1740
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins

  2. XM_034990169.1 → XP_034846060.1  neurogenic locus notch homolog protein 2 isoform X2

    Conserved Domains (12) summary
    smart00004
    Location:1406 → 1440
    NL; Domain found in Notch and Lin-12
    PHA03247
    Location:2053 → 2398
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1864 → 2051
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:167 → 203
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1928 → 1959
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1490 → 1519
    Notch; LNR domain
    pfam03154
    Location:2258 → 2452
    Atrophin-1; Atrophin-1 family
    pfam06816
    Location:1525 → 1579
    NOD; NOTCH protein
    pfam07684
    Location:1604 → 1659
    NODP; NOTCH protein
    pfam11936
    Location:2366 → 2429
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1933 → 2025
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1644 → 1725
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins
Nucleotide Protein
Heading Accession and Version

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