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tjp2a tight junction protein 2a (zona occludens 2) [ Cyclopterus lumpus (lumpfish) ]

Gene ID: 117740563, updated on 19-Mar-2024

Summary

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Gene symbol
tjp2a
Gene description
tight junction protein 2a (zona occludens 2)
See related
Ensembl:ENSCLMG00005004443
Gene type
protein coding
RefSeq status
MODEL
Organism
Cyclopterus lumpus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Cottioidei; Cottales; Cyclopteridae; Cyclopterus
Orthologs
zebrafish all
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Genomic context

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See tjp2a in Genome Data Viewer
Location:
chromosome: 12
Exon count:
26
Annotation release Status Assembly Chr Location
100 current fCycLum1.pri (GCF_009769545.1) 12 NC_046977.1 (13142489..13171313, complement)

Chromosome 12 - NC_046977.1Genomic Context describing neighboring genes Neighboring gene MAM domain-containing protein 2-like Neighboring gene amyloid-beta A4 precursor protein-binding family A member 1-like Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, beta a Neighboring gene uncharacterized LOC117740973

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_046977.1 Chromosome 12 Reference fCycLum1.pri

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cyclopterus lumpus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fCycLum1.pri

Genomic

  1. NC_046977.1 Reference fCycLum1.pri

    Range
    13142489..13171313 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034547039.1 → XP_034402930.1  tight junction protein ZO-2a isoform X3

    UniProtKB/TrEMBL
    A0A8C2WU82
    Related
    ENSCLMP00005008819.1, ENSCLMT00005009622.1
    Conserved Domains (4) summary
    smart00072
    Location:741 → 919
    GuKc; Guanylate kinase homologues
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:158 → 268
    SF-CC1; splicing factor, CC1-like family
    cl17036
    Location:641 → 706
    SH3; Src Homology 3 domain superfamily

  2. XM_034547038.1 → XP_034402929.1  tight junction protein ZO-2a isoform X2

    UniProtKB/TrEMBL
    A0A8C2WU82, A0A8C2WUR5
    Related
    ENSCLMP00005008748.1, ENSCLMT00005009551.1
    Conserved Domains (4) summary
    smart00072
    Location:745 → 923
    GuKc; Guanylate kinase homologues
    cd00992
    Location:13 → 98
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:162 → 272
    SF-CC1; splicing factor, CC1-like family
    cl17036
    Location:645 → 710
    SH3; Src Homology 3 domain superfamily

  3. XM_034547037.1 → XP_034402928.1  tight junction protein ZO-2a isoform X1

    UniProtKB/TrEMBL
    A0A8C2WT97, A0A8C2WU82
    Related
    ENSCLMP00005008798.1, ENSCLMT00005009601.1
    Conserved Domains (4) summary
    smart00072
    Location:764 → 942
    GuKc; Guanylate kinase homologues
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR01622
    Location:181 → 291
    SF-CC1; splicing factor, CC1-like family
    cl17036
    Location:664 → 729
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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