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Ap2a2 adaptor-related protein complex 2, alpha 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 11772, updated on 2-Nov-2024

Summary

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Official Symbol
Ap2a2provided by MGI
Official Full Name
adaptor-related protein complex 2, alpha 2 subunitprovided by MGI
Primary source
MGI:MGI:101920
See related
Ensembl:ENSMUSG00000002957 AllianceGenome:MGI:101920
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L25; Adtab; 2410074K14Rik
Summary
Enables disordered domain specific binding activity and protein kinase binding activity. Involved in clathrin-dependent endocytosis and synaptic vesicle endocytosis. Located in cytoplasmic vesicle. Part of AP-2 adaptor complex. Is expressed in brain. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 33.9), duodenum adult (RPKM 33.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ap2a2 in Genome Data Viewer
Location:
7 F5; 7 86.94 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141142093..141212924)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141562180..141633011)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_20492 Neighboring gene STARR-seq mESC enhancer starr_20493 Neighboring gene STARR-positive B cell enhancer ABC_E2855 Neighboring gene predicted gene, 16982 Neighboring gene microRNA 7063 Neighboring gene mucin 6, gastric Neighboring gene mucin 2 Neighboring gene mucin 5, subtypes A and C, tracheobronchial/gastric

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A structural explanation for the binding of multiple ligands by the alpha-adaptin appendage domain. Owen DJ, et al. Cell, 1999 Jun 11. PMID 10380931
  2. 1H, 15N and 13C resonance assignments and 15N-1H residual dipolar couplings for the alpha-adaptin ear-domain. Denisov AY, et al. J Biomol NMR, 2004 Jul. PMID 15213459
  3. Phosphoinositide-AP-2 interactions required for targeting to plasma membrane clathrin-coated pits. Gaidarov I, et al. J Cell Biol, 1999 Aug 23. PMID 10459011, Free PMC Article
  4. Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation. Shimomura J, et al. J Cell Physiol, 2003 Jun. PMID 12704659
  5. The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated Endocytosis to Prevent Plasma Membrane Damage during Listeria Infection. Chen C, et al. Cell Host Microbe, 2018 Jun 13. PMID 29902442, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. this study shows that IRF6 and AP2A interaction regulates epidermal development
    Title: IRF6 and AP2A Interaction Regulates Epidermal Development.
  2. Data indicate that dynamin, clathrin, adaptor protein complex-2 (AP2), and amphiphysin contribute to the depolarization-evoked entry in endocytosis.
    Title: Molecular components required for resting and stimulated endocytosis of botulinum neurotoxins by glutamatergic and peptidergic neurons.
  3. PPARalpha regulates the mouse cardiac AP2alpha2 gene in both the control and transgenic mouse.
    Title: The adaptor-related protein complex 2, alpha 2 subunit (AP2α2) gene is a peroxisome proliferator-activated receptor cardiac target gene.
  4. the AP-2 complex is not associated with the endocytosed plasma membrane-associated clathrin
    Title: The AP-2 complex is excluded from the dynamic population of plasma membrane-associated clathrin.
  5. NMR structure of mouse alpha-adaptin ear-domain
    Title: 1H, 15N and 13C resonance assignments and 15N-1H residual dipolar couplings for the alpha-adaptin ear-domain.
  6. Tensile stress induces osteoblast differentiation possibly through the induction of alpha-adaptin C gene expression.
    Title: Tensile stress induces alpha-adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in clathrin-dependent endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in clathrin-dependent endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in postsynaptic neurotransmitter receptor internalization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of hematopoietic stem cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-2 adaptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of AP-2 adaptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AP-2 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of membrane coat IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
located_in secretory granule TAS
Traceable Author Statement
more info
 PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AP-2 complex subunit alpha-2
Names
100 kDa coated vesicle protein C
adapter-related protein complex 2 alpha-2 subunit
adapter-related protein complex 2 subunit alpha-2
adaptor protein complex AP-2 subunit alpha-2
adaptor protein complex AP-2, alpha 2 subunit
adaptor-related protein complex 2 subunit alpha-2
adaptor-related protein complex AP-2, alpha 2 subunit
alpha-C adaptin
alpha-adaptin C
alpha2-adaptin
clathrin assembly protein complex 2 alpha-C large chain
plasma membrane adaptor HA2/AP2 adaptin alpha C subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357068.1 → NP_001343997.1  AP-2 complex subunit alpha-2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102524, AC158224
    UniProtKB/TrEMBL
    Q6PEE6
    Conserved Domains (4) summary
    smart00809
    Location:717 → 820
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:332 → 355
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:826 → 934
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 591
    Adaptin_N; Adaptin N terminal region

  2. NM_007459.3 → NP_031485.3  AP-2 complex subunit alpha-2 isoform 2

    See identical proteins and their annotated locations for NP_031485.3

    Status: VALIDATED

    Source sequence(s)
    AK173054, BC058099, BY729047
    Consensus CDS
    CCDS40188.1
    UniProtKB/Swiss-Prot
    P17427, Q8C2J5, Q921V0
    UniProtKB/TrEMBL
    Q6PEE6
    Related
    ENSMUSP00000003038.9, ENSMUST00000003038.12
    Conserved Domains (4) summary
    smart00809
    Location:716 → 819
    Alpha_adaptinC2; Adaptin C-terminal domain
    sd00044
    Location:331 → 354
    HEAT; HEAT repeat [structural motif]
    pfam02296
    Location:825 → 933
    Alpha_adaptin_C; Alpha adaptin AP2, C-terminal domain
    pfam01602
    Location:29 → 590
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    141142093..141212924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17427.2 GenPept UniProtKB/Swiss-Prot:P17427

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