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F12 coagulation factor XII [ Arvicanthis niloticus (Nile rat) ]

Gene ID: 117714186, updated on 19-Mar-2024

Summary

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Gene symbol
F12
Gene description
coagulation factor XII
See related
EnsemblRapid:ENSANLG00005013819
Gene type
protein coding
RefSeq status
MODEL
Organism
Arvicanthis niloticus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Arvicanthis
Orthologs
human mouse all
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Genomic context

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See F12 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
14
Annotation release Status Assembly Chr Location
100 current mArvNil1.pat.X (GCF_011762505.1) 8 NC_047665.1 (8640688..8648415)

Chromosome 8 - NC_047665.1Genomic Context describing neighboring genes Neighboring gene proline rich 7, synaptic Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_047665.1 Chromosome 8 Reference mArvNil1.pat.X

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor XII

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Arvicanthis niloticus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mArvNil1.pat.X

Genomic

  1. NC_047665.1 Reference mArvNil1.pat.X

    Range
    8640688..8648415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_034510856.1 → XP_034366747.1  coagulation factor XII

    Related
    ENSANLP00005017459.1, ENSANLT00005019770.1
    Conserved Domains (6) summary
    smart00020
    Location:366 → 603
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:96 → 131
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:133 → 173
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:41 → 88
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    pfam00008
    Location:178 → 208
    EGF; EGF-like domain
    cl00100
    Location:217 → 295
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
Nucleotide Protein
Heading Accession and Version

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