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Ap1g2 adaptor protein complex AP-1, gamma 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 11766, updated on 2-Nov-2024

Summary

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Official Symbol
Ap1g2provided by MGI
Official Full Name
adaptor protein complex AP-1, gamma 2 subunitprovided by MGI
Primary source
MGI:MGI:1328307
See related
Ensembl:ENSMUSG00000040701 AllianceGenome:MGI:1328307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G2ad; Adtg2
Summary
This gene encodes the gamma-2 subunit of the adaptor protein complex 1 (AP-1). AP-1 complex is a heterotetramer comprised of two heavy and one each of medium and small subunits. The encoded protein is a heavy subunit of AP-1 complex that regulates polarized sorting of cargo at the trans-Golgi network and endosomes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in duodenum adult (RPKM 25.5), large intestine adult (RPKM 24.3) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ap1g2 in Genome Data Viewer
Location:
14 C3; 14 28.07 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55336292..55344050, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55098835..55106593, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_36756 Neighboring gene zinc finger homeobox 2 Neighboring gene zinc finger homeobox 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_36762 Neighboring gene STARR-positive B cell enhancer ABC_E11569 Neighboring gene STARR-positive B cell enhancer ABC_E9405 Neighboring gene thiamine triphosphatase Neighboring gene junctophilin 4 Neighboring gene predicted gene, 53860

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning, expression, and localization of a novel gamma-adaptin-like molecule. Lewin DA, et al. FEBS Lett, 1998 Sep 18. PMID 9762922
  2. Calcyon, a mammalian specific NEEP21 family member, interacts with adaptor protein complex 3 (AP-3) and regulates targeting of AP-3 cargoes. Muthusamy N, et al. J Neurochem, 2012 Oct. PMID 22650988, Free PMC Article
  3. γ2 and γ1AP-1 complexes: Different essential functions and regulatory mechanisms in clathrin-dependent protein sorting. Zizioli D, et al. Eur J Cell Biol, 2017 Jun. PMID 28372831
  4. Identification and characterization of novel clathrin adaptor-related proteins. Takatsu H, et al. J Biol Chem, 1998 Sep 18. PMID 9733768
  5. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. Liu K, et al. Sci Rep, 2016 Feb 16. PMID 26880306, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118107

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
  
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
part_of AP-1 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AP-1 adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi-associated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
located_in trans-Golgi network TAS
Traceable Author Statement
more info
  
located_in transport vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in transport vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
AP-1 complex subunit gamma-like 2
Names
gamma 2-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303502.1 → NP_001290431.1  AP-1 complex subunit gamma-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001290431.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region and uses an alternate translation start site, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC157212, AK151844
    UniProtKB/TrEMBL
    Q3U9D1
    Conserved Domains (2) summary
    smart00809
    Location:464 → 572
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:2 → 361
    Adaptin_N; Adaptin N terminal region

  2. NM_007455.5 → NP_031481.2  AP-1 complex subunit gamma-like 2 isoform 1

    See identical proteins and their annotated locations for NP_031481.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC157212, AK151844
    Consensus CDS
    CCDS36929.1
    UniProtKB/Swiss-Prot
    O88512, Q2YDV3
    UniProtKB/TrEMBL
    Q3U9D1, Q3UHW6
    Related
    ENSMUSP00000043996.9, ENSMUST00000036041.15
    Conserved Domains (2) summary
    smart00809
    Location:678 → 786
    Alpha_adaptinC2; Adaptin C-terminal domain
    pfam01602
    Location:24 → 575
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55336292..55344050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88512.2 GenPept UniProtKB/Swiss-Prot:O88512

Gene LinkOut

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