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Ap1b1 adaptor protein complex AP-1, beta 1 subunit [ Mus musculus (house mouse) ]

Gene ID: 11764, updated on 2-Nov-2024

Summary

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Official Symbol
Ap1b1provided by MGI
Official Full Name
adaptor protein complex AP-1, beta 1 subunitprovided by MGI
Primary source
MGI:MGI:1096368
See related
Ensembl:ENSMUSG00000009090 AllianceGenome:MGI:1096368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adtb1; b2b1660Clo
Summary
Enables protein kinase binding activity. Acts upstream of or within determination of left/right symmetry; heart development; and kidney development. Is active in synaptic vesicle. Is expressed in primary sex cord. Used to study Kartagener syndrome; primary ciliary dyskinesia; and visceral heterotaxy. Orthologous to human AP1B1 (adaptor related protein complex 1 subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 38.3), large intestine adult (RPKM 36.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ap1b1 in Genome Data Viewer
Location:
11 A1; 11 3.15 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4897320..4992731)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4947320..5042794)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene THO complex 5 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 35321 Neighboring gene STARR-seq mESC enhancer starr_28417 Neighboring gene neurofilament, heavy polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5205 Neighboring gene predicted gene, 24958 Neighboring gene growth arrest-specific 2 like 1 Neighboring gene RAS-like, family 10, member A Neighboring gene Ewing sarcoma breakpoint region 1 Neighboring gene STARR-positive B cell enhancer ABC_E8383 Neighboring gene rhomboid domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization. Guilbaud C, et al. Mamm Genome, 1997 Sep. PMID 9271666
  2. The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Gan Y, et al. Nat Cell Biol, 2002 Aug. PMID 12105417
  3. Beta-adaptin: key molecule for microglial scavenger receptor function under oxidative stress. Manzano-León N, et al. Biochem Biophys Res Commun, 2006 Dec 22. PMID 17092488
  4. Coronary anomalies in mice with congenital heart defects. Tomanek RJ, et al. Anat Rec (Hoboken), 2015 Feb. PMID 25266175
  5. The gamma/sigma1 and alpha/sigma2 hemicomplexes of clathrin adaptors AP-1 and AP-2 harbor the dileucine recognition site. Doray B, et al. Mol Biol Cell, 2007 May. PMID 17360967, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in basolateral protein secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in clathrin coat assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within intracellular protein transport TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in melanosome assembly NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in platelet dense granule organization NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of AP-1 adaptor complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome NAS
Non-traceable Author Statement
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synaptic vesicle EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network TAS
Traceable Author Statement
more info
 PubMed 
located_in trans-Golgi network membrane NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
AP-1 complex subunit beta-1
Names
adaptor protein complex AP-1 subunit beta-1
adaptor-related protein complex AP-1, beta 1 subunit
beta-adaptin 1
beta-prime adaptin
clathrin assembly protein complex 1 beta large chain
golgi adaptor HA1/AP1 adaptin beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243043.2 → NP_001229972.1  AP-1 complex subunit beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001229972.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest variant and encodes the longest isoform (1).
    Source sequence(s)
    AL645522
    UniProtKB/TrEMBL
    Q3TVN4, Q8CC13
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 952
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  2. NM_001243044.2 → NP_001229973.1  AP-1 complex subunit beta-1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL645522
    UniProtKB/TrEMBL
    Q3TVN4
    Conserved Domains (4) summary
    smart00809
    Location:723 → 823
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:832 → 945
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  3. NM_001355659.2 → NP_001342588.1  AP-1 complex subunit beta-1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL645522
    UniProtKB/TrEMBL
    Q3TVN4, Q8CC13
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 952
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  4. NM_001355660.2 → NP_001342589.1  AP-1 complex subunit beta-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645522
    UniProtKB/TrEMBL
    Q3TVN4
    Related
    ENSMUSP00000099134.3, ENSMUST00000101613.3
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 949
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  5. NM_001417314.1 → NP_001404243.1  AP-1 complex subunit beta-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL645522

  6. NM_007454.4 → NP_031480.2  AP-1 complex subunit beta-1 isoform 2

    See identical proteins and their annotated locations for NP_031480.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL645522
    Consensus CDS
    CCDS36100.1
    UniProtKB/Swiss-Prot
    O35643, Q3TXG4, Q922E2
    UniProtKB/TrEMBL
    Q3TVN4
    Related
    ENSMUSP00000009234.10, ENSMUST00000009234.16
    Conserved Domains (4) summary
    smart00809
    Location:723 → 823
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:832 → 942
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4897320..4992731
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245487.1 → XP_030101347.1  AP-1 complex subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    Q3TVN4
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 949
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  2. XM_030245485.2 → XP_030101345.1  AP-1 complex subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    Q3TVN4, Q8CC13
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 952
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  3. XM_030245486.2 → XP_030101346.1  AP-1 complex subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    Q3TVN4
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 949
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  4. XM_030245488.2 → XP_030101348.1  AP-1 complex subunit beta-1 isoform X3

    UniProtKB/TrEMBL
    Q3TVN4
    Conserved Domains (4) summary
    smart00809
    Location:723 → 823
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:832 → 945
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  5. XM_030245489.2 → XP_030101349.1  AP-1 complex subunit beta-1 isoform X4

    UniProtKB/Swiss-Prot
    O35643, Q3TXG4, Q922E2
    UniProtKB/TrEMBL
    Q3TVN4
    Conserved Domains (4) summary
    smart00809
    Location:723 → 823
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:832 → 942
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region

  6. XM_006514462.4 → XP_006514525.1  AP-1 complex subunit beta-1 isoform X1

    See identical proteins and their annotated locations for XP_006514525.1

    UniProtKB/TrEMBL
    Q3TVN4, Q8CC13
    Conserved Domains (4) summary
    smart00809
    Location:730 → 830
    Alpha_adaptinC2; Adaptin C-terminal domain
    smart01020
    Location:839 → 952
    B2-adapt-app_C; Beta2-adaptin appendage, C-terminal sub-domain
    sd00044
    Location:51 → 75
    HEAT; HEAT repeat [structural motif]
    pfam01602
    Location:11 → 534
    Adaptin_N; Adaptin N terminal region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35643.2 GenPept UniProtKB/Swiss-Prot:O35643

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