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ZNF354B zinc finger protein 354B [ Homo sapiens (human) ]

Gene ID: 117608, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF354Bprovided by HGNC
Official Full Name
zinc finger protein 354Bprovided by HGNC
Primary source
HGNC:HGNC:17197
See related
Ensembl:ENSG00000178338 AllianceGenome:HGNC:17197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KID2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta (RPKM 4.5), endometrium (RPKM 3.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
5q35.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (178859953..178885020)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (179413219..179438286)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (178286954..178312021)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene acetoacetyl-CoA synthetase pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr5.4957 Neighboring gene Sharpr-MPRA regulatory region 5461 Neighboring gene coiled-coil domain containing 86 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:178286804-178287536 Neighboring gene uncharacterized LOC107986493 Neighboring gene RNA, U1 small nuclear 39, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16727 Neighboring gene defective in cullin neddylation 1 domain containing 3 pseudogene Neighboring gene ZFP2 zinc finger protein Neighboring gene phosphatidylinositol glycan anchor biosynthesis class F pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ25008, MGC138316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 354B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058230.3 → NP_478137.1  zinc finger protein 354B

    See identical proteins and their annotated locations for NP_478137.1

    Status: VALIDATED

    Source sequence(s)
    AA599717, AC126915, AI683630, BC104777
    Consensus CDS
    CCDS4439.1
    UniProtKB/Swiss-Prot
    A8K0V2, Q5U5Z4, Q96LW1
    Related
    ENSP00000327143.3, ENST00000322434.8
    Conserved Domains (6) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:184 → 596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:298 → 320
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    178859953..178885020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    179413219..179438286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LW1.1 GenPept UniProtKB/Swiss-Prot:Q96LW1

Gene LinkOut

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