U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HBS1 HBS1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 117365, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
HBS1provided by FlyBase
Official Full Name
HBS1provided by FlyBase
Primary source
FLYBASE:FBgn0042712
Locus tag
Dmel_CG1898
See related
AllianceGenome:FB:FBgn0042712
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1898; Dmel\CG1898; hbs1; Hbs1
Summary
Predicted to enable GTPase activity. Involved in post-transcriptional gene silencing; sperm individualization; and spermatocyte division. Located in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm anlage; mesoderm; and posterior endoderm. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HBS1 in Genome Data Viewer
Location:
62B7-62B7; 3-1.0 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1862881..1865240, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1862881..1865240, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rap1 GTPase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila. Li Z, et al. Sci Rep, 2019 Mar 1. PMID 30824860, Free PMC Article
  2. Evolution of the eukaryotic translation termination system: origins of release factors. Inagaki Y, et al. Mol Biol Evol, 2000 Jun. PMID 10833194
  3. Discovery of novel targets for antivirals: learning from flies. Martins N, et al. Curr Opin Virol, 2016 Oct. PMID 27657660
  4. The RNA surveillance complex Pelo-Hbs1 is required for transposon silencing in the Drosophila germline. Yang F, et al. EMBO Rep, 2015 Aug. PMID 26124316, Free PMC Article
  5. Nonstop-mRNA decay machinery is involved in the clearance of mRNA 5'-fragments produced by RNAi and NMD in Drosophila melanogaster cells. Hashimoto Y, et al. Biochem Biophys Res Commun, 2017 Feb 26. PMID 28115162

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
    Title: Pelota-interacting G protein Hbs1 is required for spermatogenesis in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in positive regulation of innate immune response HMP PubMed 
involved_in post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spermatocyte division IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
HBS1
Names
CG1898-PA
CG1898-PB
HBS1-PA
HBS1-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1862881..1865240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299977.1 → NP_001286906.1  HBS1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286906.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NR4, Q9W074
    Conserved Domains (2) summary
    COG5256
    Location:241 → 669
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam08938
    Location:90 → 145
    HBS1_N; HBS1 N-terminus

  2. NM_144472.4 → NP_652729.2  HBS1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652729.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q86NR4, Q9W074
    Related
    FBpp0072745
    Conserved Domains (2) summary
    COG5256
    Location:241 → 669
    TEF1; Translation elongation factor EF-1alpha (GTPase) [Translation, ribosomal structure and biogenesis]
    pfam08938
    Location:90 → 145
    HBS1_N; HBS1 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95SK5 Q95SK5
Q9W074.2 Q9W074

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous