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F12 coagulation factor XII [ Geotrypetes seraphini ]

Gene ID: 117351817, updated on 19-Mar-2024

Summary

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Gene symbol
F12
Gene description
coagulation factor XII
Gene type
protein coding
RefSeq status
MODEL
Organism
Geotrypetes seraphini
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Gymnophiona; Geotrypetes
Orthologs
human mouse all
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Genomic context

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See F12 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
13
Annotation release Status Assembly Chr Location
100 current aGeoSer1.1 (GCF_902459505.1) 18 NC_047101.1 (1081551..1107793, complement)

Chromosome 18 - NC_047101.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene alpha-2Db adrenergic receptor-like Neighboring gene profilin 3 Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene proline rich 7, synaptic

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_047101.1 Chromosome 18 Reference aGeoSer1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor XII

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Geotrypetes seraphini Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference aGeoSer1.1 Primary Assembly

Genomic

  1. NC_047101.1 Reference aGeoSer1.1 Primary Assembly

    Range
    1081551..1107793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033927660.1 → XP_033783551.1  coagulation factor XII

    UniProtKB/TrEMBL
    A0A6P8Q9J2
    Conserved Domains (4) summary
    smart00130
    Location:182 → 263
    KR; Kringle domain
    cd00054
    Location:68 → 96
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:307 → 541
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00040
    Location:13 → 54
    fn2; Fibronectin type II domain
Nucleotide Protein
Heading Accession and Version

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