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Prpsap2 phosphoribosyl pyrophosphate synthetase-associated protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117272, updated on 2-Nov-2024

Summary

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Official Symbol
Prpsap2provided by RGD
Official Full Name
phosphoribosyl pyrophosphate synthetase-associated protein 2provided by RGD
Primary source
RGD:620207
See related
EnsemblRapid:ENSRNOG00000002724 AllianceGenome:RGD:620207
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pap41
Summary
Predicted to enable enzyme regulator activity and identical protein binding activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to act upstream of or within bone development. Part of ribose phosphate diphosphokinase complex. Orthologous to human PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 172.2), Thymus (RPKM 169.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prpsap2 in Genome Data Viewer
Location:
10q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46910282..46945401, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (46410817..46445929, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (48008799..48044435, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480802 Neighboring gene GRB2-related adaptor protein Neighboring gene solute carrier family 5 member 10 Neighboring gene family with sequence similarity 83, member G Neighboring gene unc-51 like autophagy activating kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene A-kinase anchoring protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of rat cDNA for the 41-kDa phosphoribosylpyrophosphate synthetase-associated protein has a high homology to the catalytic subunits and the 39-kDa associated protein. Sonoda T, et al. Biochim Biophys Acta, 1997 Jan 3. PMID 9003449
  2. Rat liver phosphoribosyl pyrophosphate synthetase: existence of the purified enzyme as heterogeneous aggregates and identification of the catalytic subunit. Kita K, et al. J Biochem, 1989 May. PMID 2546925
  3. Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength. Bassett JH, et al. PLoS Genet, 2012. PMID 22876197, Free PMC Article
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC93257

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bone development ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribose phosphate diphosphokinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphoribosyl pyrophosphate synthase-associated protein 2
Names
41 kDa phosphoribosypyrophosphate synthetase-associated protein
PRPP synthase-associated protein 2
PRPP synthetase-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_057131.2 → NP_476472.1  phosphoribosyl pyrophosphate synthase-associated protein 2

    See identical proteins and their annotated locations for NP_476472.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87
    Conserved Domains (2) summary
    pfam13793
    Location:20 → 138
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:179 → 363
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    46910282..46945401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246436.5 → XP_006246498.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006246498.1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87
    Related
    ENSRNOP00000003697.2, ENSRNOT00000003697.5
    Conserved Domains (2) summary
    pfam13793
    Location:20 → 138
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:179 → 363
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  2. XM_063268335.1 → XP_063124405.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X3

  3. XM_039085083.2 → XP_038941011.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X6

    Conserved Domains (1) summary
    COG0462
    Location:18 → 211
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  4. XM_006246440.5 → XP_006246502.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X3

    See identical proteins and their annotated locations for XP_006246502.1

    Conserved Domains (1) summary
    COG0462
    Location:18 → 314
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]

  5. XM_006246439.5 → XP_006246501.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006246501.1

    Conserved Domains (2) summary
    pfam13793
    Location:20 → 98
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:139 → 323
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  6. XM_008767764.4 → XP_008765986.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X4

    See identical proteins and their annotated locations for XP_008765986.1

    UniProtKB/TrEMBL
    Q6AZ40
    Conserved Domains (2) summary
    pfam13793
    Location:1 → 52
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:93 → 277
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  7. XM_006246437.5 → XP_006246499.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006246499.1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87
    Conserved Domains (2) summary
    pfam13793
    Location:20 → 138
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:179 → 363
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  8. XM_039085080.2 → XP_038941008.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

    Conserved Domains (2) summary
    pfam13793
    Location:20 → 98
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:139 → 323
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  9. XM_006246435.5 → XP_006246497.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006246497.1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87
    Conserved Domains (2) summary
    pfam13793
    Location:20 → 138
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:179 → 363
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  10. XM_063268327.1 → XP_063124397.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87

  11. XM_063268337.1 → XP_063124407.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X5

  12. XM_063268330.1 → XP_063124400.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87

  13. XM_063268338.1 → XP_063124408.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X6

  14. XM_063268336.1 → XP_063124406.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X3

  15. XM_039085078.2 → XP_038941006.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87
    Conserved Domains (2) summary
    pfam13793
    Location:20 → 138
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:179 → 363
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  16. XM_063268333.1 → XP_063124403.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

  17. XM_063268331.1 → XP_063124401.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87

  18. XM_063268332.1 → XP_063124402.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

  19. XM_063268329.1 → XP_063124399.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87

  20. XM_063268328.1 → XP_063124398.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87

  21. XM_063268326.1 → XP_063124396.1  phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    O08618
    UniProtKB/TrEMBL
    A6HF87
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08618.1 GenPept UniProtKB/Swiss-Prot:O08618

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