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GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 [ Homo sapiens (human) ]

Gene ID: 117248, updated on 2-Nov-2024

Summary

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Official Symbol
GALNT15provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 15provided by HGNC
Primary source
HGNC:HGNC:21531
See related
Ensembl:ENSG00000131386 MIM:615131; AllianceGenome:HGNC:21531
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIH5; GALNT7; GALNT13; GALNTL2; GALNACT15; pp-GalNAc-T15
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation. Located in transport vesicle. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in fat (RPKM 7.2), brain (RPKM 5.4) and 14 other tissues See more
Orthologs
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Genomic context

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See GALNT15 in Genome Data Viewer
Location:
3p25.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (16174680..16248224)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (16177747..16249451)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (16216187..16273499)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124906217 Neighboring gene uncharacterized LOC124906216 Neighboring gene uncharacterized LOC124909349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19539 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16285879-16286378 Neighboring gene Sharpr-MPRA regulatory region 8904 Neighboring gene uncharacterized LOC124906218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:16297189-16297690 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19540 Neighboring gene diphthamide biosynthesis 3 Neighboring gene oxidoreductase NAD binding domain containing 1 Neighboring gene THAP domain containing 5 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15. Cheng L, et al. FEBS Lett, 2004 May 21. PMID 15147861
  2. Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries. Kumar S, et al. Osteoarthritis Cartilage, 2001 Oct. PMID 11597177
  3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. Flachsbart F, et al. Mutat Res, 2010 Dec 10. PMID 20800603
  4. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article
  5. The LIFEdb database in 2006. Mehrle A, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381901, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686H1113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in O-glycan processing TAS
Traceable Author Statement
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in transport vesicle IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase 15
Names
UDP-GalNAc transferase T15
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
galNAc-T-like protein 2
polypeptide GalNAc transferase 15
polypeptide GalNAc transferase-like protein 2
polypeptide N-acetylgalactosaminyltransferase 13
polypeptide N-acetylgalactosaminyltransferase-like protein 2
pp-GaNTase-like protein 2
pregnancy-induced hypertension syndrome-related protein 5
protein-UDP acetylgalactosaminyltransferase-like protein 2
NP_001305980.1
NP_001305981.1
NP_473451.3
XP_005264909.1
XP_054201139.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319051.2 → NP_001305980.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087858, AC090953, AL832736, DA279091
    Consensus CDS
    CCDS82742.1
    UniProtKB/TrEMBL
    C9JGI4
    Related
    ENSP00000395873.1, ENST00000437509.3
    Conserved Domains (4) summary
    cd02510
    Location:194 → 493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:507 → 614
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:505 → 592
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191 → 447
    Glyco_tranf_2_3; Glycosyltransferase like family 2

  2. NM_001319052.2 → NP_001305981.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons in the 5' coding region, and uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC090953, BC030625, BG926921, BQ005863, BQ014148, BX088662, DA358505
    UniProtKB/TrEMBL
    Q68VJ0
    Conserved Domains (2) summary
    pfam00652
    Location:35 → 158
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:1 → 23
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. NM_054110.5 → NP_473451.3  polypeptide N-acetylgalactosaminyltransferase 15 isoform 1

    See identical proteins and their annotated locations for NP_473451.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090953, AK312425, AY035399
    Consensus CDS
    CCDS33711.1
    UniProtKB/Swiss-Prot
    A6NMN1, B2R638, F1LIP6, Q86T60, Q8N3T1, Q96C46, Q96DJ5
    Related
    ENSP00000344260.5, ENST00000339732.10
    Conserved Domains (4) summary
    cd02510
    Location:194 → 493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:507 → 630
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:505 → 628
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191 → 447
    Glyco_tranf_2_3; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    16174680..16248224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264852.6 → XP_005264909.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X1

    Conserved Domains (4) summary
    cd02510
    Location:194 → 493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:507 → 591
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:505 → 591
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191 → 447
    Glyco_tranf_2_3; Glycosyltransferase like family 2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    16177747..16249451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054345164.1 → XP_054201139.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N3T1.2 GenPept UniProtKB/Swiss-Prot:Q8N3T1

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