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PLAAT5 phospholipase A and acyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 117245, updated on 14-Nov-2024

Summary

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Official Symbol
PLAAT5provided by HGNC
Official Full Name
phospholipase A and acyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:24978
See related
Ensembl:ENSG00000168004 MIM:611474; AllianceGenome:HGNC:24978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RLP1; iNAT; HRLP5; HRSL5; HRASLS5; PLAAT-5
Summary
Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 31.0), fat (RPKM 23.9) and 1 other tissue See more
Orthologs
mouse all
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Genomic context

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See PLAAT5 in Genome Data Viewer
Location:
11q12.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (63461404..63491167, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (63450660..63480424, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63228876..63258639, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 member 10 Neighboring gene solute carrier family 22 member 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63202489-63203041 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63203042-63203593 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63215327-63216263 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63216264-63217199 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:63219920-63220481 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63220482-63221042 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:63227984-63228595 Neighboring gene zinc finger protein 91 pseudogene Neighboring gene uncharacterized LOC124902822 Neighboring gene uncharacterized LOC124902684 Neighboring gene NANOG hESC enhancer GRCh37_chr11:63268635-63269162 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:63270478-63271148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:63277705-63278336 Neighboring gene galectin 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. Jin XH, et al. Biochim Biophys Acta, 2009 Jan. PMID 19000777
  2. Discovery and characterization of a Ca2+-independent phosphatidylethanolamine N-acyltransferase generating the anandamide precursor and its congeners. Jin XH, et al. J Biol Chem, 2007 Feb 9. PMID 17158102
  3. Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. Uyama T, et al. J Biol Chem, 2012 Sep 14. PMID 22825852, Free PMC Article
  4. SR protein kinases promote splicing of nonconsensus introns. Lipp JJ, et al. Nat Struct Mol Biol, 2015 Aug. PMID 26167880
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylserine 1-acylhydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A1 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A1 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phospholipase A and acyltransferase 5
Names
Ca(2+)-independent N-acyltransferase
H-rev107-like protein 5
HRAS like suppressor family member 5
HRAS-like suppressor 5
calcium-independent phosphatidylethanolamine N-acyltransferase
lecithin-retinol acyltransferase (LRAT)-like protein-1
phospholipase A/acyltransferase-5
testicular tissue protein Li 90
NP_001140200.2
NP_001140201.2
NP_473449.2
XP_011543053.1
XP_011543054.1
XP_047282295.1
XP_047282296.1
XP_054223588.1
XP_054223589.1
XP_054223590.1
XP_054223591.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146728.2 → NP_001140200.2  phospholipase A and acyltransferase 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region compared to variant 1 that results in a frameshift. It encodes isoform 3, which has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP000484, AP001591
    Consensus CDS
    CCDS53647.1
    UniProtKB/TrEMBL
    B4DY88
    Related
    ENSP00000443873.1, ENST00000539221.5
    Conserved Domains (1) summary
    pfam04970
    Location:142 → 233
    LRAT; Lecithin retinol acyltransferase

  2. NM_001146729.2 → NP_001140201.2  phospholipase A and acyltransferase 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AP000484, AP001591
    Consensus CDS
    CCDS53646.1
    UniProtKB/TrEMBL
    Q8NE88
    Related
    ENSP00000444809.1, ENST00000540857.6
    Conserved Domains (1) summary
    pfam04970
    Location:132 → 235
    LRAT; Lecithin retinol acyltransferase

  3. NM_054108.4 → NP_473449.2  phospholipase A and acyltransferase 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP000484, AP001591
    Consensus CDS
    CCDS8044.1
    UniProtKB/Swiss-Prot
    B7X6T1, F5GZ87, F5H4Y9, Q96KN8
    UniProtKB/TrEMBL
    Q8NE88
    Related
    ENSP00000301790.4, ENST00000301790.4
    Conserved Domains (1) summary
    pfam04970
    Location:142 → 245
    LRAT; Lecithin retinol acyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    63461404..63491167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544752.3 → XP_011543054.1  phospholipase A and acyltransferase 5 isoform X2

    Conserved Domains (1) summary
    pfam04970
    Location:57 → 133
    LRAT; Lecithin retinol acyltransferase

  2. XM_011544751.4 → XP_011543053.1  phospholipase A and acyltransferase 5 isoform X1

    UniProtKB/TrEMBL
    Q8NE88
    Conserved Domains (1) summary
    pfam04970
    Location:131 → 234
    LRAT; Lecithin retinol acyltransferase

  3. XM_047426339.1 → XP_047282295.1  phospholipase A and acyltransferase 5 isoform X3

  4. XM_047426340.1 → XP_047282296.1  phospholipase A and acyltransferase 5 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    63450660..63480424 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367614.1 → XP_054223589.1  phospholipase A and acyltransferase 5 isoform X2

  2. XM_054367613.1 → XP_054223588.1  phospholipase A and acyltransferase 5 isoform X1

  3. XM_054367615.1 → XP_054223590.1  phospholipase A and acyltransferase 5 isoform X3

  4. XM_054367616.1 → XP_054223591.1  phospholipase A and acyltransferase 5 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KN8.2 GenPept UniProtKB/Swiss-Prot:Q96KN8

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