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LOC117152611 DPP4 -4.2 kb glucocorticoid response element [ Homo sapiens (human) ]

Gene ID: 117152611, updated on 10-Oct-2023

Summary

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Gene symbol
LOC117152611
Gene description
DPP4 -4.2 kb glucocorticoid response element
Gene type
biological region
Feature type(s)
misc_feature: nucleotide_motif
protein_bind
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region represents a glucocorticoid response element (GRE) that exists 4.2 kb upstream of the DPP4 (dipeptidyl peptidase 4) gene, which encodes a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and it may play a similar role for other acute respiratory syndrome coronaviruses, including SARS-CoV and SARS-CoV-2 (COVID-19 virus). This element binds the glucocorticoid receptor (GR, also known as NR3C1), which mediates glucocorticoid-responsive gene expression in macrophage-like THP-1 cells. [provided by RefSeq, Apr 2020]
Annotation information
Note: This locus has been reviewed for its involvement in coronavirus biology, and is involved in host gene regulation.
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Genomic context

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Location:
2q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (162078687..162078798)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (162535324..162535435)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (162935197..162935308)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:162854969-162855469 Neighboring gene dipeptidyl peptidase 4 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_54939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16715 Neighboring gene Sharpr-MPRA regulatory region 3711 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12061 Neighboring gene DPP4 promoter region Neighboring gene translocase of inner mitochondrial membrane 8A pseudogene 1 Neighboring gene DPP4 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:162949234-162950433 Neighboring gene EIF3E pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 10348 Neighboring gene uncharacterized LOC101929532 Neighboring gene GCG promoter region Neighboring gene glucagon

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glucocorticoids mobilize macrophages by transcriptionally up-regulating the exopeptidase DPP4. Diaz-Jimenez D, et al. J Biol Chem, 2020 Mar 6. PMID 31988243, Free PMC Article
  2. Acute Respiratory Infection in Human Dipeptidyl Peptidase 4-Transgenic Mice Infected with Middle East Respiratory Syndrome Coronavirus. Iwata-Yoshikawa N, et al. J Virol, 2019 Mar 15. PMID 30626685, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_068154.1 

    Range
    101..212
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    162078687..162078798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    162535324..162535435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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