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TADA1 transcriptional adaptor 1 [ Homo sapiens (human) ]

Gene ID: 117143, updated on 5-Mar-2024

Summary

Official Symbol
TADA1provided by HGNC
Official Full Name
transcriptional adaptor 1provided by HGNC
Primary source
HGNC:HGNC:30631
See related
Ensembl:ENSG00000152382 MIM:612763; AllianceGenome:HGNC:30631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADA1; HFI1; hADA1; STAF42; TADA1L
Summary
TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]
Expression
Ubiquitous expression in brain (RPKM 9.2), bone marrow (RPKM 7.8) and 25 other tissues See more
Orthologs
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Genomic context

Location:
1q24.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (166856510..166876264, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (166202343..166222098, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (166825747..166845501, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene calponin 2 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1512 Neighboring gene pogo transposable element derived with KRAB domain Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1513 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:166852951-166853452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:166853453-166853952 Neighboring gene deoxyuridine triphosphatase pseudogene 6 Neighboring gene uncharacterized LOC124904450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:166871233-166871733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2028 Neighboring gene immunoglobulin like domain containing receptor 2 Neighboring gene uncharacterized LOC124904449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1515 Neighboring gene Sharpr-MPRA regulatory region 1052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2029 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2030

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of SAGA complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of SAGA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional adapter 1
Names
SPT3-associated factor 42 (STAF42)
transcriptional adapter 1-like protein
transcriptional adaptor 1 (HFI1 homolog, yeast)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053053.4NP_444281.1  transcriptional adapter 1

    See identical proteins and their annotated locations for NP_444281.1

    Status: VALIDATED

    Source sequence(s)
    BC015401, CN399642
    Consensus CDS
    CCDS1255.1
    UniProtKB/Swiss-Prot
    A8K4J9, Q96BN2
    Related
    ENSP00000356848.4, ENST00000367874.5
    Conserved Domains (1) summary
    pfam12767
    Location:7193
    SAGA-Tad1; Transcriptional regulator of RNA polII, SAGA, subunit

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    166856510..166876264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    166202343..166222098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)