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Gjb4 gap junction protein, beta 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117055, updated on 10-Jul-2024

Summary

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Official Symbol
Gjb4provided by RGD
Official Full Name
gap junction protein, beta 4provided by RGD
Primary source
RGD:621829
See related
EnsemblRapid:ENSRNOG00000026910 AllianceGenome:RGD:621829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cxnb; Gjb4o; Cx30.3; Cnx30.3; Cx30.3o; Cnx30.3o
Summary
Predicted to enable gap junction channel activity. Predicted to be involved in cell-cell signaling and gap junction-mediated intercellular transport. Predicted to act upstream of or within olfactory behavior and sensory perception of smell. Predicted to be located in cell junction; nucleolus; and nucleoplasm. Predicted to be integral component of plasma membrane. Predicted to be part of connexin complex. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and erythrokeratodermia variabilis et progressiva 2. Orthologous to human GJB4 (gap junction protein beta 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 6.8), Lung (RPKM 1.1) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gjb4 in Genome Data Viewer
Location:
5q36
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (144948231..144964014, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (139675776..139679551, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (145416343..145421122, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene gap junction protein, alpha 4 Neighboring gene gap junction protein, beta 3 Neighboring gene gap junction protein, beta 5 Neighboring gene uncharacterized LOC134479031

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel expression patterns of connexin 30.3 in adult rat cochlea. Wang WH, et al. Hear Res, 2010 Jun 14. PMID 20184948
  2. Rat connexins 30.3 and 31 are expressed in the kidney. Tucker MA, et al. Exp Cell Res, 1994 Jul. PMID 7517368
  3. Novel mutation in GJB4 gene (connexin 30.3) in a family with erythrokeratodermia variabilis. Sbidian E, et al. Acta Derm Venereol, 2013 Mar 27. PMID 23037955
  4. Genetic heterogeneity in erythrokeratodermia variabilis: novel mutations in the connexin gene GJB4 (Cx30.3) and genotype-phenotype correlations. Richard G, et al. J Invest Dermatol, 2003 Apr. PMID 12648223
  5. Mutation in the gene for connexin 30.3 in a family with erythrokeratodermia variabilis. Macari F, et al. Am J Hum Genet, 2000 Nov. PMID 11017804, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicate the presence and localization of Cx30.3 in the rat cochlea.
    Title: Novel expression patterns of connexin 30.3 in adult rat cochlea.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables gap junction channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gap junction channel activity IEA
Inferred from Electronic Annotation
more info
  
enables gap junction channel activity ISO
Inferred from Sequence Orthology
more info
  
enables gap junction channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell-cell signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in gap junction-mediated intercellular transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gap junction-mediated intercellular transport ISO
Inferred from Sequence Orthology
more info
  
involved_in gap junction-mediated intercellular transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in olfactory behavior IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within olfactory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
part_of connexin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of connexin complex IEA
Inferred from Electronic Annotation
more info
  
part_of connexin complex ISO
Inferred from Sequence Orthology
more info
  
part_of connexin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
gap junction beta-4 protein
Names
connexin 30.3o
connexin b
connexin-30.3
gap junction membrane channel protein beta 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001389258.1 → NP_001376187.1  gap junction beta-4 protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/Swiss-Prot
    P36380
    UniProtKB/TrEMBL
    A6ISD2, F1M8I1
    Related
    ENSRNOP00000033893.2, ENSRNOT00000037128.5
    Conserved Domains (1) summary
    pfam00029
    Location:2 → 210
    Connexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    144948231..144964014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287084.1 → XP_063143154.1  gap junction beta-4 protein isoform X1

    UniProtKB/Swiss-Prot
    P36380

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053984.2: Suppressed sequence

    Description
    NM_053984.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36380.1 GenPept UniProtKB/Swiss-Prot:P36380

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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