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PSEN2 presenilin 2 [ Rhinolophus ferrumequinum (greater horseshoe bat) ]

Gene ID: 117018604, updated on 30-Mar-2024

Summary

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Gene symbol
PSEN2
Gene description
presenilin 2
See related
EnsemblRapid:ENSRFEG00010014406
Gene type
protein coding
RefSeq status
MODEL
Organism
Rhinolophus ferrumequinum
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea; Rhinolophidae; Rhinolophinae; Rhinolophus
Orthologs
human mouse all
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Genomic context

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See PSEN2 in Genome Data Viewer
Location:
chromosome: 27
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_02 current mRhiFer1_v1.p (GCF_004115265.2) 27 NC_046310.1 (14640451..14665070)

Chromosome 27 - NC_046310.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC117018606 Neighboring gene enhancer of rudimentary homolog Neighboring gene transfer RNA serine (anticodon ACU) Neighboring gene uncharacterized LOC117018474 Neighboring gene coenzyme Q8A Neighboring gene CDC42 binding protein kinase alpha Neighboring gene histone chaperone ASF1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_046310.1 Chromosome 27 Reference mRhiFer1_v1.p

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_004115265.2-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRhiFer1_v1.p

Genomic

  1. NC_046310.1 Reference mRhiFer1_v1.p

    Range
    14640451..14665070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033099704.1 → XP_032955595.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A671F789, A0A671F7H8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  2. XM_033099706.1 → XP_032955597.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A671F789, A0A671F7H8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  3. XM_033099702.1 → XP_032955593.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A671F789, A0A671F7H8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  4. XM_033099708.1 → XP_032955599.1  presenilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A671F789
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 437
    Presenilin

  5. XM_033099703.1 → XP_032955594.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A671F789, A0A671F7H8
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

  6. XM_033099705.1 → XP_032955596.1  presenilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A671F789, A0A671F7H8
    Related
    ENSRFEP00010021666.1, ENSRFET00010023584.2
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin

RNA

  1. XR_004422260.1 RNA Sequence

  2. XR_004422259.1 RNA Sequence

Nucleotide Protein
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