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NOTCH2 notch receptor 2 [ Rhinolophus ferrumequinum (greater horseshoe bat) ]

Gene ID: 117014380, updated on 30-Mar-2024

Summary

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Gene symbol
NOTCH2
Gene description
notch receptor 2
See related
EnsemblRapid:ENSRFEG00010010773
Gene type
protein coding
RefSeq status
MODEL
Organism
Rhinolophus ferrumequinum
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Rhinolophoidea; Rhinolophidae; Rhinolophinae; Rhinolophus
Orthologs
human mouse all
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Genomic context

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See NOTCH2 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_02 current mRhiFer1_v1.p (GCF_004115265.2) 22 NC_046305.1 (48971308..49119062, complement)

Chromosome 22 - NC_046305.1Genomic Context describing neighboring genes Neighboring gene regenerating family member 4 Neighboring gene ADAM metallopeptidase domain 30 Neighboring gene ubiquitin-conjugating enzyme E2 D3-like Neighboring gene myomegalin Neighboring gene SEC22 homolog B, vesicle trafficking protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_046305.1 Chromosome 22 Reference mRhiFer1_v1.p

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables Notch binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to tumor cell IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurogenic locus notch homolog protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_004115265.2-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRhiFer1_v1.p

Genomic

  1. NC_046305.1 Reference mRhiFer1_v1.p

    Range
    48971308..49119062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_033092161.1 → XP_032948052.1  neurogenic locus notch homolog protein 2

    UniProtKB/TrEMBL
    A0A671EW70, A0A7J7SY54
    Related
    ENSRFEP00010015878.1, ENSRFET00010017337.2
    Conserved Domains (11) summary
    smart00004
    Location:1421 → 1455
    NL; Domain found in Notch and Lin-12
    PHA03247
    Location:2068 → 2465
    PHA03247; large tegument protein UL36; Provisional
    COG0666
    Location:1879 → 2066
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00054
    Location:182 → 218
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    sd00045
    Location:1943 → 1974
    ANK; ANK repeat [structural motif]
    pfam00066
    Location:1505 → 1534
    Notch; LNR domain
    pfam06816
    Location:1540 → 1594
    NOD; NOTCH protein
    pfam07684
    Location:1619 → 1674
    NODP; NOTCH protein
    pfam11936
    Location:2381 → 2444
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:1948 → 2040
    Ank_2; Ankyrin repeats (3 copies)
    cd21703
    Location:1659 → 1740
    JMTM_Notch2; juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins
Nucleotide Protein
Heading Accession and Version

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