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ART5 ADP-ribosyltransferase 5 [ Homo sapiens (human) ]

Gene ID: 116969, updated on 3-Apr-2024

Summary

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Official Symbol
ART5provided by HGNC
Official Full Name
ADP-ribosyltransferase 5provided by HGNC
Primary source
HGNC:HGNC:24049
See related
Ensembl:ENSG00000167311 MIM:610625; AllianceGenome:HGNC:24049
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTC5
Summary
The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Biased expression in testis (RPKM 6.5), ovary (RPKM 2.3) and 5 other tissues See more
Orthologs
mouse all
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Genomic context

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See ART5 in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3638512..3642379, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3683946..3687812, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3659742..3663609, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene XRCC1 N-terminal domain containing 1, C-terminal like pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3636766-3637290 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3637291-3637815 Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3662929-3663642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3081 Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. Okazaki IJ, et al. Annu Rev Nutr, 1999. PMID 10448534
  2. LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation. Shi F, et al. Cell Oncol (Dordr), 2023 Jun. PMID 36913068
  3. The family of toxin-related ecto-ADP-ribosyltransferases in humans and the mouse. Glowacki G, et al. Protein Sci, 2002 Jul. PMID 12070318, Free PMC Article
  4. Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5. Glowacki G, et al. Gene, 2001 Sep 19. PMID 11587854
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
    Title: LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC22848

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 5
Names
ADP-ribosyltransferase C2 and C3 toxin-like 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
mono(ADP-ribosyl)transferase 5
NP_001073004.1
NP_001284597.1
NP_443750.2
XP_005252836.1
XP_006718199.1
XP_011518181.1
XP_054223583.1
XP_054223584.1
XP_054223585.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079536.2 → NP_001073004.1  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_001073004.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a different 5' UTR compared to transcript variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC060812, AW241897, CD557970, Y16835
    Consensus CDS
    CCDS7743.1
    UniProtKB/Swiss-Prot
    C9IYG7, Q6UX84, Q86W02, Q96L15
    Related
    ENSP00000352992.4, ENST00000359918.8
    Conserved Domains (1) summary
    pfam01129
    Location:28 → 254
    ART; NAD:arginine ADP-ribosyltransferase

  2. NM_001297668.2 → NP_001284597.1  ecto-ADP-ribosyltransferase 5 isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon and an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC060812, AY358466
    Consensus CDS
    CCDS73242.1
    UniProtKB/Swiss-Prot
    Q96L15
    Related
    ENSP00000380257.3, ENST00000397067.7
    Conserved Domains (1) summary
    cl00173
    Location:28 → 196
    VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  3. NM_053017.5 → NP_443750.2  ecto-ADP-ribosyltransferase 5 isoform a precursor

    See identical proteins and their annotated locations for NP_443750.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC060812, BC014577
    Consensus CDS
    CCDS7743.1
    UniProtKB/Swiss-Prot
    C9IYG7, Q6UX84, Q86W02, Q96L15
    Related
    ENSP00000380258.3, ENST00000397068.8
    Conserved Domains (1) summary
    pfam01129
    Location:28 → 254
    ART; NAD:arginine ADP-ribosyltransferase

RNA

  1. NR_123732.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and and alternate splice junction at the 5' end of the second exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC060812, BC014577, HY018364

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3638512..3642379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005252779.4 → XP_005252836.1  ecto-ADP-ribosyltransferase 5 isoform X2

    UniProtKB/TrEMBL
    H7C1W0
    Related
    ENSP00000402737.2, ENST00000453353.2
    Conserved Domains (1) summary
    pfam01129
    Location:28 → 254
    ART; NAD:arginine ADP-ribosyltransferase

  2. XM_011519879.4 → XP_011518181.1  ecto-ADP-ribosyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_011518181.1

    UniProtKB/TrEMBL
    H7C1W0
    Conserved Domains (1) summary
    pfam01129
    Location:28 → 254
    ART; NAD:arginine ADP-ribosyltransferase

  3. XM_006718136.5 → XP_006718199.1  ecto-ADP-ribosyltransferase 5 isoform X1

    See identical proteins and their annotated locations for XP_006718199.1

    UniProtKB/TrEMBL
    H7C1W0
    Conserved Domains (1) summary
    pfam01129
    Location:28 → 254
    ART; NAD:arginine ADP-ribosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3683946..3687812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367609.1 → XP_054223584.1  ecto-ADP-ribosyltransferase 5 isoform X2

  2. XM_054367608.1 → XP_054223583.1  ecto-ADP-ribosyltransferase 5 isoform X1

  3. XM_054367610.1 → XP_054223585.1  ecto-ADP-ribosyltransferase 5 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96L15.4 GenPept UniProtKB/Swiss-Prot:Q96L15

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