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Akr1c20 aldo-keto reductase family 1, member C20 [ Mus musculus (house mouse) ]

Gene ID: 116852, updated on 2-Nov-2024

Summary

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Official Symbol
Akr1c20provided by MGI
Official Full Name
aldo-keto reductase family 1, member C20provided by MGI
Primary source
MGI:MGI:2151104
See related
Ensembl:ENSMUSG00000054757 AllianceGenome:MGI:2151104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610528B18Rik
Summary
Predicted to enable several functions, including geranylgeranyl reductase activity; oxidoreductase activity, acting on CH-OH group of donors; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including doxorubicin metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C4 (aldo-keto reductase family 1 member C4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 7.9), liver E18 (RPKM 4.0) and 1 other tissue See more
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Genomic context

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See Akr1c20 in Genome Data Viewer
Location:
13 A1; 13 2.51 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (4536855..4573353, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (4486856..4523354, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9973 Neighboring gene STARR-seq mESC enhancer starr_33508 Neighboring gene aldo-keto reductase family 1, member C6 Neighboring gene STARR-seq mESC enhancer starr_33510 Neighboring gene STARR-seq mESC enhancer starr_33513 Neighboring gene STARR-seq mESC enhancer starr_33514 Neighboring gene predicted gene, 40657 Neighboring gene aldo-keto reductase family 1, member C21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family. Matsumoto K, et al. Biol Pharm Bull, 2006 Mar. PMID 16508162
  2. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. Vergnes L, et al. J Lipid Res, 2003 Mar. PMID 12562828
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables Delta4-3-oxosteroid 5beta-reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables aldo-keto reductase (NADPH) activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables aldo-keto reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase (B-specific) activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables bile acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bile acid binding ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables chlordecone reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables geranylgeranyl reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketoreductase activity ISO
Inferred from Sequence Orthology
more info
  
enables ketosteroid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ketosteroid monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
  
enables testosterone dehydrogenase [NAD(P)+] activity ISO
Inferred from Sequence Orthology
more info
  
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in doxorubicin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in progesterone metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prostaglandin metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within steroid biosynthetic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1, member C20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311132.1 → NP_001298061.1  aldo-keto reductase family 1, member C20

    See identical proteins and their annotated locations for NP_001298061.1

    Status: VALIDATED

    Source sequence(s)
    AC166056, AI661346, AK012162
    Consensus CDS
    CCDS79161.1
    UniProtKB/TrEMBL
    A0A1Y7VMC8, Q8VC77
    Related
    ENSMUSP00000079232.6, ENSMUST00000080361.13
    Conserved Domains (2) summary
    COG0656
    Location:5 → 317
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:16 → 297
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    4536855..4573353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247130.1 → XP_030102990.1  aldo-keto reductase family 1, member C20 isoform X3

    UniProtKB/TrEMBL
    A0A1Y7VMC8
    Conserved Domains (1) summary
    cl00470
    Location:6 → 259
    AKR_SF; Aldo-keto reductase (AKR) superfamily

  2. XM_006516466.1 → XP_006516529.1  aldo-keto reductase family 1, member C20 isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VMC8
    Related
    ENSMUSP00000152648.2, ENSMUST00000221564.2
    Conserved Domains (1) summary
    cd19108
    Location:6 → 279
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

  3. XM_006516465.1 → XP_006516528.1  aldo-keto reductase family 1, member C20 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VMC8
    Conserved Domains (1) summary
    cd19108
    Location:6 → 286
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_054080.1: Suppressed sequence

    Description
    NM_054080.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
Nucleotide Protein Strain
Heading Accession and Version

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