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Prelp proline arginine-rich end leucine-rich repeat [ Mus musculus (house mouse) ]

Gene ID: 116847, updated on 29-Oct-2024

Summary

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Official Symbol
Prelpprovided by MGI
Official Full Name
proline arginine-rich end leucine-rich repeatprovided by MGI
Primary source
MGI:MGI:2151110
See related
Ensembl:ENSMUSG00000041577 AllianceGenome:MGI:2151110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SLRR2A; 7330409J17Rik
Summary
Predicted to enable heparin binding activity. Acts upstream of or within cellular senescence. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; connective tissue; eye; nervous system; and reproductive system. Orthologous to human PRELP (proline and arginine rich end leucine rich repeat protein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 99.9), lung adult (RPKM 77.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Prelp in Genome Data Viewer
Location:
1 E4; 1 58.02 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133838042..133857820, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133910304..133930102, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31515 Neighboring gene opticin Neighboring gene predicted gene 1627 Neighboring gene bone marrow associated noncoding RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elevated PRELP expression in heart and liver fibrosis promotes collagen production. Yamauchi Y, et al. Biochem Biophys Res Commun, 2024 Nov 19. PMID 39369540
  2. Characterization and expression of murine PRELP. Grover J, et al. Matrix Biol, 2001 Dec. PMID 11731272
  3. PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/β-catenin signalling pathway. Zhang Y, et al. Cardiovasc J Afr, 2022 Sep-Oct 23. PMID 35788244, Free PMC Article
  4. The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis. Rucci N, et al. J Cell Biol, 2009 Nov 30. PMID 19951916, Free PMC Article
  5. AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice. Birke MT, et al. Gene Ther, 2014 May. PMID 24670995, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated PRELP expression in heart and liver fibrosis promotes collagen production.
    Title: Elevated PRELP expression in heart and liver fibrosis promotes collagen production.
  2. PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/beta-catenin signalling pathway.
    Title: PRELP promotes myocardial fibrosis and ventricular remodelling after acute myocardial infarction by the wnt/β-catenin signalling pathway.
  3. Therefore, this study established a new role of PRELP in modulating beta-catenin/connexin43 pathway and osteoblast differentiation.
    Title: PRELP (proline/arginine-rich end leucine-rich repeat protein) promotes osteoblastic differentiation of preosteoblastic MC3T3-E1 cells by regulating the β-catenin pathway.
  4. when delivered via an AAV vector to the retina of mice, PRELP inhibited laser-induced choroidal neovascularization by 60%. PRELP reduced deposition of membrane attack complex in vivo by 25.5%.
    Title: AAV-mediated expression of human PRELP inhibits complement activation, choroidal neovascularization and deposition of membrane attack complex in mice.
  5. PRELP has a role in skeletal remodeling.
    Title: The glycosaminoglycan-binding domain of PRELP acts as a cell type-specific NF-kappaB inhibitor that impairs osteoclastogenesis.
  6. expressed in cartilage throughout both fetal development and post-natal life
    Title: Characterization and expression of murine PRELP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent conferring compression resistance RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prolargin
Names
proline-arginine-rich end leucine-rich repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_054077.4 → NP_473418.3  prolargin precursor

    See identical proteins and their annotated locations for NP_473418.3

    Status: VALIDATED

    Source sequence(s)
    AK037150, AK047480
    Consensus CDS
    CCDS15300.1
    UniProtKB/Swiss-Prot
    Q9JK53
    UniProtKB/TrEMBL
    Q543S0, Q8CAZ9
    Related
    ENSMUSP00000048803.6, ENSMUST00000048432.6
    Conserved Domains (3) summary
    PRK15370
    Location:129 → 349
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00013
    Location:68 → 103
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:100 → 123
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133838042..133857820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529084.5 → XP_006529147.1  prolargin isoform X1

    See identical proteins and their annotated locations for XP_006529147.1

    UniProtKB/Swiss-Prot
    Q9JK53
    UniProtKB/TrEMBL
    Q543S0, Q8CAZ9
    Conserved Domains (3) summary
    PRK15370
    Location:129 → 349
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00013
    Location:68 → 103
    LRRNT; Leucine rich repeat N-terminal domain
    sd00033
    Location:100 → 123
    LRR_RI; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JK53.2 GenPept UniProtKB/Swiss-Prot:Q9JK53

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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