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Pip4k2a phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 116723, updated on 2-Nov-2024

Summary

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Symbol
Pip4k2aprovided by RGD
Full Name
phosphatidylinositol-5-phosphate 4-kinase type 2 alphaprovided by RGD
Primary source
RGD:621708
See related
EnsemblRapid:ENSRNOG00000016670 AllianceGenome:RGD:621708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pip5k2a
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity; 1-phosphatidylinositol-5-phosphate 4-kinase activity; and protein homodimerization activity. Predicted to be involved in several processes, including 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; autophagosome-lysosome fusion; and megakaryocyte development. Predicted to be located in autophagosome; cytosol; and lysosome. Predicted to be active in plasma membrane. Orthologous to human PIP4K2A (phosphatidylinositol-5-phosphate 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Spleen (RPKM 240.7), Thymus (RPKM 121.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pip4k2a in Genome Data Viewer
Location:
17q12.3
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (86405080..86576597, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (81496669..81668180, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (85533056..85748843, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 6 Neighboring gene uncharacterized LOC120097847 Neighboring gene hypothetical LOC100361451 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene armadillo repeat containing 3 Neighboring gene PICALM interacting mitotic regulator like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis. Schulze H, et al. Blood, 2006 May 15. PMID 16434494, Free PMC Article
  2. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Clarke JH, et al. Biochem J, 2015 Mar 1. PMID 25495341, Free PMC Article
  3. Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. Ishihara H, et al. J Biol Chem, 1998 Apr 10. PMID 9535851
  4. Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization. Clarke JH, et al. Biochem J, 2013 Aug 15. PMID 23758345, Free PMC Article
  5. PI(5)P regulates autophagosome biogenesis. Vicinanza M, et al. Mol Cell, 2015 Jan 22. PMID 25578879, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-5-phosphate 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in autophagosome-lysosome fusion IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagosome-lysosome fusion ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in megakaryocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in megakaryocyte development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated cholesterol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle-mediated cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in autophagosome IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Names
1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha
1-phosphatidylinositol-5-phosphate 4-kinase A
PI(5)P 4-kinase type II alpha
PIP4KII-alpha
PIPK2 alpha
diphosphoinositide kinase 2-alpha
phosphatidylinositol 5-phosphate 4-kinase type II alpha
phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
phosphatidylinositol-5-phosphate 4-kinase type-2 alpha-like
NP_446378.1
XP_038951232.1
XP_038951233.1
XP_038951234.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053926.2 → NP_446378.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

    See identical proteins and their annotated locations for NP_446378.1

    Status: VALIDATED

    Source sequence(s)
    AB032899, BQ782736, CB715008, CO573943, CV077559, DV713604
    UniProtKB/Swiss-Prot
    Q9R0I8
    UniProtKB/TrEMBL
    A6JM97
    Related
    ENSRNOP00000022375.8, ENSRNOT00000022375.9
    Conserved Domains (1) summary
    cd17309
    Location:27 → 403
    PIPKc_PIP5K2A; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP5K2A) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    86405080..86576597 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095306.2 → XP_038951234.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X3

    UniProtKB/TrEMBL
    A6JM97
    Conserved Domains (1) summary
    cl28923
    Location:27 → 352
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  2. XM_039095305.2 → XP_038951233.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X2

    Conserved Domains (1) summary
    cl28923
    Location:72 → 361
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

  3. XM_039095304.2 → XP_038951232.1  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1

    UniProtKB/TrEMBL
    A6JM97
    Conserved Domains (1) summary
    cl28923
    Location:27 → 283
    PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9R0I8.1 GenPept UniProtKB/Swiss-Prot:Q9R0I8

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