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Cyth3 cytohesin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116693, updated on 28-Oct-2024

Summary

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Official Symbol
Cyth3provided by RGD
Official Full Name
cytohesin 3provided by RGD
Primary source
RGD:620399
See related
EnsemblRapid:ENSRNOG00000001065 AllianceGenome:RGD:620399
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sec7; Pscd3; Sec7C
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in Golgi vesicle transport. Predicted to act upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Predicted to be located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Orthologous to human CYTH3 (cytohesin 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Adrenal (RPKM 457.5), Lung (RPKM 456.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyth3 in Genome Data Viewer
Location:
12p11
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (15953781..16076584, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (10840137..10933792, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (12877559..12907771, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481266 Neighboring gene ubiquitin specific peptidase 42 Neighboring gene collagen alpha-1(I) chain-like Neighboring gene small integral membrane protein 10 like 3 Neighboring gene family with sequence similarity 220, member A Neighboring gene Rac family small GTPase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors. Malaby AW, et al. Proc Natl Acad Sci U S A, 2013 Aug 27. PMID 23940353, Free PMC Article
  2. Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. Venkateswarlu K, et al. Biochem J, 1998 Oct 1. PMID 9742223, Free PMC Article
  3. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. Franco M, et al. Proc Natl Acad Sci U S A, 1998 Aug 18. PMID 9707577, Free PMC Article
  4. Rat homologues of yeast sec7p. Telemenakis I, et al. Eur J Cell Biol, 1997 Oct. PMID 9352219
  5. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Klarlund JK, et al. Science, 1997 Mar 28. PMID 9072969

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124579

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in Golgi vesicle transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi vesicle transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of epithelial cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytohesin-3
Names
PH, SEC7 and coiled-coil domain-containing protein 3
SEC7 homolog C
pleckstrin homology, Sec7 and coiled/coil domains 3
rSec7-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053912.2 → NP_446364.2  cytohesin-3

    See identical proteins and their annotated locations for NP_446364.2

    Status: PROVISIONAL

    Source sequence(s)
    BC101884
    UniProtKB/Swiss-Prot
    P97696
    UniProtKB/TrEMBL
    Q3T1J6
    Related
    ENSRNOP00000001412.9, ENSRNOT00000001412.9
    Conserved Domains (2) summary
    cd01252
    Location:263 → 382
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:66 → 248
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    15953781..16076584 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271013.1 → XP_063127083.1  cytohesin-3 isoform X3

    UniProtKB/TrEMBL
    A6K1K3

  2. XM_063271012.1 → XP_063127082.1  cytohesin-3 isoform X2

    Related
    ENSRNOP00000109621.1, ENSRNOT00000129902.1

  3. XM_039089028.2 → XP_038944956.1  cytohesin-3 isoform X3

    UniProtKB/Swiss-Prot
    P97696
    UniProtKB/TrEMBL
    A6K1K3
    Related
    ENSRNOP00000112358.1, ENSRNOT00000132895.1
    Conserved Domains (2) summary
    cd01252
    Location:215 → 334
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:18 → 200
    Sec7; Sec7 domain

  4. XM_039089024.2 → XP_038944952.1  cytohesin-3 isoform X1

    UniProtKB/Swiss-Prot
    P97696
    Related
    ENSRNOP00000103429.1, ENSRNOT00000128862.1
    Conserved Domains (2) summary
    cd01252
    Location:335 → 454
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:138 → 320
    Sec7; Sec7 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97696.1 GenPept UniProtKB/Swiss-Prot:P97696

Gene LinkOut

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