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Cyth1 cytohesin 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116691, updated on 2-Nov-2024

Summary

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Official Symbol
Cyth1provided by RGD
Official Full Name
cytohesin 1provided by RGD
Primary source
RGD:620397
See related
EnsemblRapid:ENSRNOG00000043381 AllianceGenome:RGD:620397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sec7; Pscd1
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in presynaptic modulation of chemical synaptic transmission. Is active in neuromuscular junction. Is extrinsic component of presynaptic membrane. Orthologous to human CYTH1 (cytohesin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 96.9), Heart (RPKM 85.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cyth1 in Genome Data Viewer
Location:
10q32.2-q32.3
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103901376..103984496, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (103402727..103485826, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (107197983..107281285, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095221 Neighboring gene dynein, axonemal, heavy chain 17 Neighboring gene uncharacterized LOC134480725 Neighboring gene ubiquitin specific peptidase 36 Neighboring gene TIMP metallopeptidase inhibitor 2 Neighboring gene CEP295 N-terminal like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A presynaptic role for the ADP ribosylation factor (ARF)-specific GDP/GTP exchange factor msec7-1. Ashery U, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927699, Free PMC Article
  2. Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate. Stricker R, et al. Biochim Biophys Acta, 2003 Sep 23. PMID 14499594
  3. Rat homologues of yeast sec7p. Telemenakis I, et al. Eur J Cell Biol, 1997 Oct. PMID 9352219
  4. Structural basis and mechanism of autoregulation in 3-phosphoinositide-dependent Grp1 family Arf GTPase exchange factors. DiNitto JP, et al. Mol Cell, 2007 Nov 30. PMID 18042453, Free PMC Article
  5. Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors. Ogasawara M, et al. J Biol Chem, 2000 Feb 4. PMID 10652308

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that oligomerization of inositol phosphate/phosphatidylinositol binding proteins such as cytoadhesin 1 and centaurin alpha 1 can modulate their function in a tissue-dependent manner.
    Title: Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of epithelial cell polarity ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of epithelial cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in presynaptic modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in presynaptic modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in extrinsic component of presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extrinsic component of presynaptic membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
cytohesin-1
Names
PH, SEC7 and coiled-coil domain-containing protein 1
SEC7 homolog A
pleckstrin homology, Sec7 and coiled-coil domains 1
pleckstrin homology, Sec7 and coiled/coil domains 1(cytohesin 1)
rSec7-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053910.1 → NP_446362.1  cytohesin-1

    See identical proteins and their annotated locations for NP_446362.1

    Status: VALIDATED

    Source sequence(s)
    U83895
    UniProtKB/Swiss-Prot
    P97694
    UniProtKB/TrEMBL
    A0A8I6AK04
    Conserved Domains (2) summary
    cd01252
    Location:259 → 379
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    103901376..103984496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247784.5 → XP_006247846.1  cytohesin-1 isoform X2

    See identical proteins and their annotated locations for XP_006247846.1

    UniProtKB/TrEMBL
    A0A8I6AK04, B2GUV0, D4A8L6
    Related
    ENSRNOP00000004196.6, ENSRNOT00000004196.8
    Conserved Domains (2) summary
    cd01252
    Location:259 → 378
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:62 → 244
    Sec7; Sec7 domain

  2. XM_063268306.1 → XP_063124376.1  cytohesin-1 isoform X1

    Related
    ENSRNOP00000093390.2, ENSRNOT00000108086.2

  3. XM_006247785.5 → XP_006247847.1  cytohesin-1 isoform X3

    See identical proteins and their annotated locations for XP_006247847.1

    UniProtKB/TrEMBL
    A0A8I6AK04
    Conserved Domains (2) summary
    cd01252
    Location:200 → 320
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:3 → 185
    Sec7; Sec7 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97694.1 GenPept UniProtKB/Swiss-Prot:P97694

Gene LinkOut

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