U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cap2 cyclase associated actin cytoskeleton regulatory protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116653, updated on 17-Aug-2024

Summary

Go to the top of the page Help
Official Symbol
Cap2provided by RGD
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 2provided by RGD
Primary source
RGD:620310
See related
EnsemblRapid:ENSRNOG00000043350 AllianceGenome:RGD:620310
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity; adenylate cyclase binding activity; and identical protein binding activity. Predicted to be involved in cAMP-mediated signaling; cell morphogenesis; and regulation of adenylate cyclase activity. Predicted to be located in postsynaptic density. Predicted to be active in cytoplasm. Orthologous to human CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 507.1), Heart (RPKM 442.0) and 4 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Cap2 in Genome Data Viewer
Location:
17p14
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (18260462..18409681, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (18054234..18203453, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (18441614..18592866, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene nucleoporin 153 Neighboring gene uncharacterized LOC120097854 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene uncharacterized LOC134482694 Neighboring gene uncharacterized LOC120097855 Neighboring gene zinc finger protein 120 like 3 Neighboring gene RNA binding motif protein 24

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. An actin-binding protein, CAP, is expressed in a subset of rat taste bud cells. Ishimaru Y, et al. Neuroreport, 2001 Feb 12. PMID 11209926
  2. Differential expression of CAP and CAP2 in adult rat tissues. Swiston J, et al. Gene, 1995 Nov 20. PMID 8522189
  3. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
  4. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article
  5. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in presynaptic actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
adenylyl cyclase-associated protein 2
Names
CAP 2
CAP, adenylate cyclase-associated protein, 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053874.1 → NP_446326.1  adenylyl cyclase-associated protein 2

    See identical proteins and their annotated locations for NP_446326.1

    Status: PROVISIONAL

    Source sequence(s)
    U31935
    UniProtKB/Swiss-Prot
    P52481
    UniProtKB/TrEMBL
    A0A8L2R883, A6J714
    Related
    ENSRNOP00000062591.2, ENSRNOT00000065742.4
    Conserved Domains (2) summary
    pfam01213
    Location:7 → 65
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:323 → 475
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    18260462..18409681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253754.4 → XP_006253816.1  adenylyl cyclase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006253816.1

    UniProtKB/Swiss-Prot
    P52481
    UniProtKB/TrEMBL
    A0A8L2R883, A6J714
    Conserved Domains (2) summary
    pfam01213
    Location:7 → 65
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:323 → 475
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  2. XM_006253753.5 → XP_006253815.1  adenylyl cyclase-associated protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006253815.1

    UniProtKB/Swiss-Prot
    P52481
    UniProtKB/TrEMBL
    A0A8L2R883, A6J714
    Conserved Domains (2) summary
    pfam01213
    Location:7 → 65
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:323 → 475
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  3. XM_039095302.2 → XP_038951230.1  adenylyl cyclase-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P52481
    UniProtKB/TrEMBL
    A0A8L2R883, A6J714
    Conserved Domains (2) summary
    pfam01213
    Location:7 → 65
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:323 → 475
    CAP_C; Adenylate cyclase associated (CAP) C terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52481.1 GenPept UniProtKB/Swiss-Prot:P52481

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools