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Srp54a signal recognition particle 54A [ Rattus norvegicus (Norway rat) ]

Gene ID: 116650, updated on 28-Oct-2024

Summary

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Official Symbol
Srp54aprovided by RGD
Official Full Name
signal recognition particle 54Aprovided by RGD
Primary source
RGD:621390
See related
EnsemblRapid:ENSRNOG00000032776 AllianceGenome:RGD:621390
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Srp54
Summary
Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane; exocrine pancreas development; and neutrophil chemotaxis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 181.5), Adrenal (RPKM 152.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Srp54a in Genome Data Viewer
Location:
6q23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78322308..78362017)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72587584..72626878)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (75996629..76035768)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cofilin 2 Neighboring gene bromodomain adjacent to zinc finger domain, 1A Neighboring gene uncharacterized LOC108351236 Neighboring gene U6 spliceosomal RNA Neighboring gene RIKEN cDNA 2700097009 gene like Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1 Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene protein only RNase P catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Modulation of the signal recognition particle 54-kDa subunit (SRP54) in rat preosteoblasts by the extracellular matrix. Traianedes K, et al. J Biol Chem, 1995 Sep 8. PMID 7673110
  2. Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages. Römisch K, et al. Arthritis Res Ther, 2006. PMID 16469117, Free PMC Article
  3. Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting. Bacher G, et al. Nature, 1996 May 16. PMID 8622769
  4. A complex of the signal sequence binding protein and the SRP RNA promotes translocation of nascent proteins. Hauser S, et al. EMBO J, 1995 Nov 15. PMID 8521805, Free PMC Article
  5. GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation. Miller JD, et al. Nature, 1993 Nov 25. PMID 8247130

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 7S RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 7S RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables 7S RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables endoplasmic reticulum signal peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endoplasmic reticulum signal peptide binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition ISO
Inferred from Sequence Orthology
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in exocrine pancreas development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in granulocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neutrophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to ER ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
NOT located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting IEA
Inferred from Electronic Annotation
more info
  
part_of signal recognition particle, endoplasmic reticulum targeting ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
signal recognition particle subunit SRP54
Names
signal recognition particle 54 kDa protein
NP_446323.1
XP_006240159.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053871.1 → NP_446323.1  signal recognition particle subunit SRP54

    See identical proteins and their annotated locations for NP_446323.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079117
    UniProtKB/Swiss-Prot
    Q6AYB5
    UniProtKB/TrEMBL
    A0A8I6A4J0
    Related
    ENSRNOP00000104350.1, ENSRNOT00000131173.1
    Conserved Domains (1) summary
    TIGR01425
    Location:2 → 430
    SRP54_euk; signal recognition particle protein SRP54

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    78322308..78362017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240097.5 → XP_006240159.1  signal recognition particle subunit SRP54 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A4J0
    Related
    ENSRNOP00000085749.1, ENSRNOT00000098782.2
    Conserved Domains (4) summary
    COG0541
    Location:2 → 440
    Ffh; Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular transport]
    pfam00448
    Location:102 → 294
    SRP54; SRP54-type protein, GTPase domain
    pfam02881
    Location:6 → 83
    SRP54_N; SRP54-type protein, helical bundle domain
    pfam02978
    Location:326 → 385
    SRP_SPB; Signal peptide binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYB5.1 GenPept UniProtKB/Swiss-Prot:Q6AYB5

Gene LinkOut

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