U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rtn1 reticulon 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116644, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rtn1provided by RGD
Official Full Name
reticulon 1provided by RGD
Primary source
RGD:620986
See related
EnsemblRapid:ENSRNOG00000004794 AllianceGenome:RGD:620986
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Nsp
Summary
Predicted to be involved in endoplasmic reticulum tubular network formation; negative regulation of amyloid-beta formation; and nervous system development. Located in smooth endoplasmic reticulum. Orthologous to human RTN1 (reticulon 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 780.3) and Spleen (RPKM 36.2) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rtn1 in Genome Data Viewer
Location:
6q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (96499137..96719340, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (90763212..90983436, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (94951016..95177477, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene JNK1/MAPK8-associated membrane protein Neighboring gene coiled-coil domain containing 175 Neighboring gene peptidylprolyl isomerase D, pseudogene 7 Neighboring gene large ribosomal subunit protein eL8-like Neighboring gene uncharacterized LOC134479399 Neighboring gene ribosomal protein L36A, pseudogene 20

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress. Lin M, et al. Brain Res Bull, 2019 Jul. PMID 31002913
  2. RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy. Ling J, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Feb 4. PMID 33372676
  3. Knockdown of RTN1-C attenuates traumatic neuronal injury through regulating intracellular Ca(2+) homeostasis. Fan XX, et al. Neurochem Int, 2018 Dec. PMID 30352262
  4. RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways. Gong L, et al. Cell Death Dis, 2017 Oct 5. PMID 28981095, Free PMC Article
  5. Intracellular compartmentalization of two differentially spliced s-rex/NSP mRNAs in neurons. Baka ID, et al. Mol Cell Neurosci, 1996 Apr. PMID 8793864

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
    Title: RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
  2. High glucose significantly increases RTN1-C expression in OGD/R-treated cells. RTN1-C affects high glucose-treated OGD/R cells by exacerbating ER stress.
    Title: RTN1-C is involved in high glucose-aggravated neuronal cell subjected to oxygen-glucose deprivation and reoxygenation injury via endoplasmic reticulum stress.
  3. Knock-down of RTN1-c protected neurons against traumatic neuronal injury via preservation of calcium homeostasis.
    Title: Knockdown of RTN1-C attenuates traumatic neuronal injury through regulating intracellular Ca(2+) homeostasis.
  4. Collectively, these data support for the first time that RTN1-C may represent a novel candidate for therapies against cerebral ischemia/reperfusion injury.
    Title: RTN1-C mediates cerebral ischemia/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways.
  5. This study identified the intracellular calcium release channel ryanodine receptor 2 as a direct binding partner of RTN1A.
    Title: Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.
  6. neuroendocrine-specific protein-A (NSP-A) as ethanol-responsive gene in the fetal rat brain
    Title: Differential display identifies neuroendocrine-specific protein-A (NSP-A) and interferon-inducible protein 10 (IP-10) as ethanol-responsive genes in the fetal rat brain.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum tubular network formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of amyloid-beta formation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in smooth endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
reticulon-1
Names
S-rex
neuroendocrine-specific protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053865.2 → NP_446317.2  reticulon-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q64547, Q64548
    UniProtKB/TrEMBL
    A0A8I6GGJ4
    Related
    ENSRNOP00000087943.1, ENSRNOT00000118381.2
    Conserved Domains (1) summary
    PHA03307
    Location:310 → 583
    PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    96499137..96719340 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008764690.4 → XP_008762912.1  reticulon-1 isoform X1

    See identical proteins and their annotated locations for XP_008762912.1

    UniProtKB/TrEMBL
    A6HC34
    Related
    ENSRNOP00000006373.3, ENSRNOT00000006373.6
    Conserved Domains (1) summary
    pfam02453
    Location:23 → 185
    Reticulon
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64548.1 GenPept UniProtKB/Swiss-Prot:Q64548

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials