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DYSF dysferlin [ Hylobates moloch (silvery gibbon) ]

Gene ID: 116483192, updated on 18-Mar-2024

Summary

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Gene symbol
DYSF
Gene description
dysferlin
See related
EnsemblRapid:ENSHMOG00010016925
Gene type
protein coding
RefSeq status
MODEL
Organism
Hylobates moloch
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Hylobates
Orthologs
human mouse all
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Genomic context

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See DYSF in Genome Data Viewer
Location:
chromosome: Un
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2023_07 current HMol_V3 (GCF_009828535.3) Unplaced Scaffold NW_026652290.1 (52917792..53152421, complement)
100 previous assembly HMol (GCF_009828535.1) Unplaced Scaffold NW_022454859.1 (52917792..53152501, complement)

NW_026652290.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450 26B1 Neighboring gene uncharacterized LOC131381341 Neighboring gene uncharacterized LOC131381362 Neighboring gene U6 spliceosomal RNA Neighboring gene zinc finger protein 638 Neighboring gene poly(A) binding protein interacting protein 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-tubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monocyte activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dysferlin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009828535.3-RS_2023_07

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference HMol_V3

Genomic

  1. NW_026652290.1 Reference HMol_V3

    Range
    52917792..53152421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_032176991.2 → XP_032032882.1  dysferlin isoform X15

    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1138 → 1266
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1565 → 1688
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1799 → 1930
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:932 → 988
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:772 → 845
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:684 → 741
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1943 → 2031
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1334 → 1404
    C2; C2 domain

  2. XM_032176986.2 → XP_032032877.1  dysferlin isoform X11

    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1138 → 1266
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1586 → 1709
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1820 → 1951
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:932 → 988
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:772 → 845
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:684 → 741
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1964 → 2052
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1334 → 1404
    C2; C2 domain

  3. XM_032176988.2 → XP_032032879.1  dysferlin isoform X13

    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1152 → 1280
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 554
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1579 → 1702
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1813 → 1944
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:946 → 1002
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:786 → 859
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:698 → 755
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1957 → 2045
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1348 → 1418
    C2; C2 domain

  4. XM_032176982.2 → XP_032032873.1  dysferlin isoform X7

    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1152 → 1280
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 554
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1600 → 1723
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1834 → 1965
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:946 → 1002
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:786 → 859
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:698 → 755
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1978 → 2066
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1348 → 1418
    C2; C2 domain

  5. XM_032176984.2 → XP_032032875.1  dysferlin isoform X9

    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1169 → 1297
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1596 → 1719
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1830 → 1961
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:963 → 1019
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:803 → 876
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1974 → 2062
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1365 → 1435
    C2; C2 domain

  6. XM_032176977.2 → XP_032032868.1  dysferlin isoform X3

    Related
    ENSHMOP00010021001.1, ENSHMOT00010026801.1
    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1169 → 1297
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1617 → 1740
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1851 → 1982
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:963 → 1019
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:803 → 876
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1995 → 2083
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1365 → 1435
    C2; C2 domain

  7. XM_032176980.2 → XP_032032871.1  dysferlin isoform X5

    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1183 → 1311
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 585
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1610 → 1733
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1844 → 1975
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:977 → 1033
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:817 → 890
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:729 → 786
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1988 → 2076
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1379 → 1449
    C2; C2 domain

  8. XM_032176989.2 → XP_032032880.1  dysferlin isoform X14

    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1139 → 1267
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1566 → 1689
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1800 → 1931
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:933 → 989
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:773 → 846
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 742
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1944 → 2032
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1335 → 1405
    C2; C2 domain

  9. XM_032176985.2 → XP_032032876.1  dysferlin isoform X10

    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1139 → 1267
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1587 → 1710
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1821 → 1952
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:933 → 989
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:773 → 846
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 742
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1965 → 2053
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1335 → 1405
    C2; C2 domain

  10. XM_032176987.2 → XP_032032878.1  dysferlin isoform X12

    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1281
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 555
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1580 → 1703
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1814 → 1945
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:947 → 1003
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:787 → 860
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:699 → 756
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1958 → 2046
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1349 → 1419
    C2; C2 domain

  11. XM_032176981.2 → XP_032032872.1  dysferlin isoform X6

    Related
    ENSHMOP00010020962.1, ENSHMOT00010026751.1
    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1281
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 555
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1601 → 1724
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1835 → 1966
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:947 → 1003
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:787 → 860
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:699 → 756
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1979 → 2067
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1349 → 1419
    C2; C2 domain

  12. XM_032176983.2 → XP_032032874.1  dysferlin isoform X8

    Conserved Domains (12) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1597 → 1720
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1831 → 1962
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1975 → 2063
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1366 → 1436
    C2; C2 domain

  13. XM_032176976.2 → XP_032032867.1  dysferlin isoform X2

    Related
    ENSHMOP00010020899.1, ENSHMOT00010026669.1
    Conserved Domains (12) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1618 → 1741
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1852 → 1983
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1996 → 2084
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1366 → 1436
    C2; C2 domain

  14. XM_032176978.2 → XP_032032869.1  dysferlin isoform X4

    Related
    ENSHMOP00010020945.1, ENSHMOT00010026731.1
    Conserved Domains (12) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1184 → 1312
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 586
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1611 → 1734
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1845 → 1976
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:978 → 1034
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:818 → 891
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:730 → 787
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1989 → 2077
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1380 → 1450
    C2; C2 domain

  15. XM_032176975.2 → XP_032032866.1  dysferlin isoform X1

    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1183 → 1311
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 585
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1645 → 1768
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1879 → 2010
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:977 → 1033
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:817 → 890
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:729 → 786
    FerA; FerA (NUC095) domain
    pfam16165
    Location:2023 → 2111
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1393 → 1463
    C2; C2 domain
Nucleotide Protein
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