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IL22RA2 interleukin 22 receptor subunit alpha 2 [ Homo sapiens (human) ]

Gene ID: 116379, updated on 11-Apr-2024

Summary

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Official Symbol
IL22RA2provided by HGNC
Official Full Name
interleukin 22 receptor subunit alpha 2provided by HGNC
Primary source
HGNC:HGNC:14901
See related
Ensembl:ENSG00000164485 MIM:606648; AllianceGenome:HGNC:14901
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; ZCYTOR16; IL-22R-alpha-2
Summary
This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See IL22RA2 in Genome Data Viewer
Location:
6q23.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137143820..137173644, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138332180..138362006, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137464957..137494781, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137311375-137312331 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137322965-137323508 Neighboring gene neuroblastoma highly expressed DDX5 stabilizing lncRNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90349 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90351 Neighboring gene interleukin 20 receptor subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17577 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17578 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17579 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137382319-137382457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25128 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:137410449-137410629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25129 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25130 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25131 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90355 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25133 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90359 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90362 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137492881-137493639 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90370 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:137500946-137502145 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90375 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17580 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:137540162-137540892 Neighboring gene interferon gamma receptor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25139 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:137618853-137619479 Neighboring gene uncharacterized LOC105378017

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. IL-22BP production is heterogeneously distributed in Crohn's disease. Fantou A, et al. Front Immunol, 2022. PMID 36311796, Free PMC Article
  2. Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression. Støy S, et al. Clin Transl Gastroenterol, 2020 Aug. PMID 32955203, Free PMC Article
  3. The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis. Gómez-Fernández P, et al. Cells, 2020 Jan 10. PMID 31936765, Free PMC Article
  4. Crystallization and preliminary X-ray diffraction analysis of human IL-22 bound to its soluble decoy receptor IL-22BP. Watanabe L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Feb 1. PMID 19193995, Free PMC Article
  5. A novel, soluble homologue of the human IL-10 receptor with preferential expression in placenta. Gruenberg BH, et al. Genes Immun, 2001 Oct. PMID 11607789

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.
    Title: Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.
  2. IL-22BP production is heterogeneously distributed in Crohn's disease.
    Title: IL-22BP production is heterogeneously distributed in Crohn's disease.
  3. Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.
    Title: Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.
  4. Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
    Title: Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.
  5. The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.
    Title: The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.
  6. Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
    Title: Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.
  7. Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression.
    Title: Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression.
  8. The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis.
    Title: The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis.
  9. Our results demonstrate a pathogenic role of IL-22BP in three species with a potential mechanism of action involving T cell polarization
    Title: IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
  10. Upon silencing of interleukin 22 receptor subunit alpha 2 (IL22RA2) expression in immature dendritic cells (moDC), molecular chaperone GRP78 (GRP78) levels were significantly reduced, suggesting that native IL22RA2 expression naturally contributes to upregulating GRP78 levels in these cells.
    Title: Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC150509, MGC150510

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-22 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-22 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-22 receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in interleukin-22-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in extracellular space NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
interleukin-22 receptor subunit alpha-2
Names
cytokine receptor class-II member 10
cytokine receptor family type 2, soluble 1
interleukin 22 receptor, alpha 2
interleukin 22-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052962.3 → NP_443194.1  interleukin-22 receptor subunit alpha-2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI824338, AJ313162, AY040566
    Consensus CDS
    CCDS5182.1
    UniProtKB/Swiss-Prot
    Q08AH7, Q6UWM1, Q969J5, Q96A41, Q96QR0
    Related
    ENSP00000296980.2, ENST00000296980.7
    Conserved Domains (2) summary
    pfam01108
    Location:24 → 146
    Tissue_fac; Tissue factor
    pfam09294
    Location:158 → 263
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

  2. NM_181309.2 → NP_851826.1  interleukin-22 receptor subunit alpha-2 isoform 2 precursor

    See identical proteins and their annotated locations for NP_851826.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040566
    Consensus CDS
    CCDS5183.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000296979.4, ENST00000349184.9
    Conserved Domains (2) summary
    pfam01108
    Location:23 → 114
    Tissue_fac; Tissue factor
    pfam09294
    Location:126 → 231
    Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

  3. NM_181310.2 → NP_851827.1  interleukin-22 receptor subunit alpha-2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_851827.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons in the coding region, which leads to a translation frameshift, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI824338, AJ313161, AY040568
    Consensus CDS
    CCDS5184.1
    UniProtKB/Swiss-Prot
    Q969J5
    Related
    ENSP00000340920.3, ENST00000339602.3
    Conserved Domains (1) summary
    pfam01108
    Location:24 → 114
    Tissue_fac; Tissue factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    137143820..137173644 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    138332180..138362006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969J5.1 GenPept UniProtKB/Swiss-Prot:Q969J5

Gene LinkOut

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