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PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [ Strigops habroptila (Kakapo) ]

Gene ID: 115606321, updated on 17-Mar-2024

Summary

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Gene symbol
PIK3C2A
Gene description
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Gene type
protein coding
RefSeq status
MODEL
Organism
Strigops habroptila
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Psittaciformes; Psittacidae; Strigops
Orthologs
human mouse all
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Genomic context

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See PIK3C2A in Genome Data Viewer
Location:
chromosome: 4
Exon count:
35
Annotation release Status Assembly Chr Location
101 current bStrHab1.2.pri (GCF_004027225.2) 4 NC_046358.1 (53392982..53462435)
100 previous assembly bStrHab1_v1.p (GCF_004027225.1) 4 NC_044280.1 (53387591..53462435)

Chromosome 4 - NC_046358.1Genomic Context describing neighboring genes Neighboring gene potassium inwardly rectifying channel subfamily J member 11 Neighboring gene nucleobindin 2 Neighboring gene ribosomal protein S13 Neighboring gene pleckstrin homology domain containing A7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Strigops habroptila Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bStrHab1.2.pri

Genomic

  1. NC_046358.1 Reference bStrHab1.2.pri

    Range
    53392982..53462435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_032919865.1 → XP_032775756.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Conserved Domains (6) summary
    cd07289
    Location:1438 → 1546
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 862
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1575 → 1692
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1055 → 1407
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:435 → 528
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:886 → 1050
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  2. XM_030482044.1 → XP_030337904.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Conserved Domains (6) summary
    cd07289
    Location:1438 → 1546
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 862
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1575 → 1692
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1055 → 1407
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:435 → 528
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:886 → 1050
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  3. XM_030482046.1 → XP_030337906.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    Conserved Domains (6) summary
    cd07289
    Location:1436 → 1544
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:690 → 860
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1573 → 1690
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1053 → 1405
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:884 → 1048
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    pfam00794
    Location:434 → 526
    PI3K_rbd; PI3-kinase family, ras-binding domain

  4. XM_030482042.1 → XP_030337902.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    Conserved Domains (6) summary
    cd07289
    Location:1438 → 1546
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 862
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1575 → 1692
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1055 → 1407
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:435 → 528
    PI3K_rbd; PI3-kinase family, ras-binding domain
    cl00271
    Location:886 → 1050
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...

  5. XM_030482049.1 → XP_030337909.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X5

    Conserved Domains (6) summary
    cd07289
    Location:1382 → 1490
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 806
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1519 → 1636
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:999 → 1351
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:830 → 994
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    pfam00794
    Location:436 → 528
    PI3K_rbd; PI3-kinase family, ras-binding domain

  6. XM_030482048.1 → XP_030337908.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X4

    Conserved Domains (6) summary
    cd07289
    Location:1390 → 1498
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:644 → 814
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1527 → 1644
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1007 → 1359
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:838 → 1002
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    pfam00794
    Location:436 → 528
    PI3K_rbd; PI3-kinase family, ras-binding domain

  7. XM_030482050.1 → XP_030337910.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X6

    Conserved Domains (6) summary
    cd07289
    Location:1436 → 1544
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:690 → 860
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1573 → 1694
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1053 → 1405
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:884 → 1048
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    pfam00794
    Location:434 → 526
    PI3K_rbd; PI3-kinase family, ras-binding domain

  8. XM_030482045.1 → XP_030337905.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    Conserved Domains (6) summary
    cd07289
    Location:1436 → 1544
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:690 → 860
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1573 → 1690
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1053 → 1405
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:884 → 1048
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    pfam00794
    Location:434 → 526
    PI3K_rbd; PI3-kinase family, ras-binding domain

  9. XM_030482047.1 → XP_030337907.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

    Conserved Domains (6) summary
    cd07289
    Location:1438 → 1546
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:692 → 862
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1575 → 1696
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd05176
    Location:1055 → 1407
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    cl00271
    Location:886 → 1050
    PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
    pfam00794
    Location:436 → 528
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein
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