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dlg3 discs, large homolog 3 (Drosophila) [ Gadus morhua (Atlantic cod) ]

Gene ID: 115552344, updated on 17-Mar-2024

Summary

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Gene symbol
dlg3
Gene description
discs, large homolog 3 (Drosophila)
See related
Ensembl:ENSGMOG00000003948
Gene type
protein coding
RefSeq status
MODEL
Organism
Gadus morhua
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Zeiogadaria; Gadariae; Gadiformes; Gadoidei; Gadidae; Gadus
Orthologs
human zebrafish all
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Genomic context

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See dlg3 in Genome Data Viewer
Location:
chromosome: 10
Exon count:
33
Annotation release Status Assembly Chr Location
100 current gadMor3.0 (GCF_902167405.1) 10 NC_044057.1 (19935874..20011075)

Chromosome 10 - NC_044057.1Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 11 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 2 Neighboring gene testis expressed 11 Neighboring gene kinase insert domain receptor like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_044057.1 Chromosome 10 Reference gadMor3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
disks large homolog 3
Names
discs large MAGUK scaffold protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gadus morhua Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference gadMor3.0 Primary Assembly

Genomic

  1. NC_044057.1 Reference gadMor3.0 Primary Assembly

    Range
    19935874..20011075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030368358.1 → XP_030224218.1  disks large homolog 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:582 → 648
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:464 → 542
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:739 → 917
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:373 → 465
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  2. XM_030368360.1 → XP_030224220.1  disks large homolog 3 isoform X4

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Related
    ENSGMOP00000028577.1, ENSGMOT00000040949.1
    Conserved Domains (6) summary
    cd12029
    Location:576 → 642
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:458 → 536
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:733 → 911
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:373 → 459
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  3. XM_030368365.1 → XP_030224225.1  disks large homolog 3 isoform X9

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:563 → 629
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:445 → 523
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:720 → 898
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:373 → 446
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  4. XM_030368363.1 → XP_030224223.1  disks large homolog 3 isoform X7

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:587 → 653
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:469 → 547
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:725 → 903
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:378 → 470
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  5. XM_030368357.1 → XP_030224217.1  disks large homolog 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:587 → 653
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:469 → 547
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:744 → 922
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:378 → 470
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  6. XM_030368361.1 → XP_030224221.1  disks large homolog 3 isoform X5

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:574 → 640
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:456 → 534
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:731 → 909
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:378 → 457
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  7. XM_030368359.1 → XP_030224219.1  disks large homolog 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:581 → 647
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:463 → 541
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:738 → 916
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:378 → 464
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  8. XM_030368362.1 → XP_030224222.1  disks large homolog 3 isoform X6

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:568 → 634
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:450 → 528
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:725 → 903
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 108
    L27_1
    pfam10600
    Location:378 → 451
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 192
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  9. XM_030368366.1 → XP_030224226.1  disks large homolog 3 isoform X10

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (6) summary
    cd12029
    Location:562 → 628
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:444 → 522
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:719 → 897
    Guanylate_kin; Guanylate kinase
    pfam09058
    Location:24 → 83
    L27_1
    pfam10600
    Location:353 → 445
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:105 → 167
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  10. XM_030368370.1 → XP_030224230.1  disks large homolog 3 isoform X13

    UniProtKB/TrEMBL
    A0A8C5AAB9
    Conserved Domains (5) summary
    cd12029
    Location:466 → 532
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:348 → 426
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:623 → 801
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:257 → 349
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:9 → 71
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  11. XM_030368367.1 → XP_030224227.1  disks large homolog 3 isoform X11

    UniProtKB/TrEMBL
    A0A8C5FHS1
    Related
    ENSGMOP00000037519.1, ENSGMOT00000049491.1
    Conserved Domains (5) summary
    cd12029
    Location:560 → 626
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:442 → 520
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:717 → 895
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:351 → 443
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 170
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  12. XM_030368369.1 → XP_030224229.1  disks large homolog 3 isoform X12

    UniProtKB/TrEMBL
    A0A8C5FHS1
    Related
    ENSGMOP00000004214.2, ENSGMOT00000004344.2
    Conserved Domains (5) summary
    cd12029
    Location:547 → 613
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:429 → 507
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:704 → 882
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:351 → 430
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:130 → 170
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  13. XM_030368364.1 → XP_030224224.1  disks large homolog 3 isoform X8

    UniProtKB/TrEMBL
    A0A8C5AHK0
    Conserved Domains (5) summary
    cd12029
    Location:471 → 537
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:353 → 431
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:628 → 806
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:262 → 354
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 76
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  14. XM_030368371.1 → XP_030224231.1  disks large homolog 3 isoform X14

    UniProtKB/TrEMBL
    A0A8C5FHS1
    Conserved Domains (5) summary
    cd12029
    Location:461 → 527
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    cd00992
    Location:343 → 421
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:618 → 796
    Guanylate_kin; Guanylate kinase
    pfam10600
    Location:252 → 344
    PDZ_assoc; PDZ-associated domain of NMDA receptors
    pfam10608
    Location:36 → 66
    MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

  15. XM_030368372.1 → XP_030224232.1  disks large homolog 3 isoform X15

    Conserved Domains (3) summary
    cd12029
    Location:163 → 229
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:44 → 128
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00625
    Location:320 → 498
    Guanylate_kin; Guanylate kinase

  16. XM_030368373.1 → XP_030224233.1  disks large homolog 3 isoform X16

    Conserved Domains (3) summary
    cd12029
    Location:150 → 216
    SH3_DLG3; Src Homology 3 domain of Disks Large homolog 3
    smart00228
    Location:31 → 115
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    pfam00625
    Location:307 → 485
    Guanylate_kin; Guanylate kinase

  17. XM_030368375.1 → XP_030224235.1  disks large homolog 3 isoform X18

    Conserved Domains (2) summary
    pfam00625
    Location:176 → 354
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:19 → 85
    SH3; Src Homology 3 domain superfamily

  18. XM_030368374.1 → XP_030224234.1  disks large homolog 3 isoform X17

    Conserved Domains (2) summary
    pfam00625
    Location:195 → 373
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:38 → 104
    SH3; Src Homology 3 domain superfamily

  19. XM_030368376.1 → XP_030224236.1  disks large homolog 3 isoform X18

    Conserved Domains (2) summary
    pfam00625
    Location:176 → 354
    Guanylate_kin; Guanylate kinase
    cl17036
    Location:19 → 85
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
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