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FCRL1 Fc receptor like 1 [ Homo sapiens (human) ]

Gene ID: 115350, updated on 5-Mar-2024

Summary

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Official Symbol
FCRL1provided by HGNC
Official Full Name
Fc receptor like 1provided by HGNC
Primary source
HGNC:HGNC:18509
See related
Ensembl:ENSG00000163534 MIM:606508; AllianceGenome:HGNC:18509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRH1; IFGP1; IRTA5; CD307a
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains three extracellular C2-like immunoglobulin domains, a transmembrane domain and a cytoplasmic domain with two immunoreceptor-tyrosine activation motifs. This protein may play a role in the regulation of cancer cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Expression
Biased expression in lymph node (RPKM 18.4), spleen (RPKM 14.4) and 3 other tissues See more
Orthologs
all
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Genomic context

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Location:
1q23.1
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157794403..157820120, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156931472..156957188, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157764193..157789910, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene 9 Neighboring gene Fc receptor like 2 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157739405-157740604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1895 Neighboring gene CD5 molecule like Neighboring gene mitochondrial ribosomal protein S21 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. [Expression of human B-cell specific receptor FCRL1 in normal individuals and in patients with autoimmune diseases]. Baranov KO, et al. Mol Biol (Mosk), 2012 May-Jun. PMID 22888639
  2. FCRL1 on chronic lymphocytic leukemia, hairy cell leukemia, and B-cell non-Hodgkin lymphoma as a target of immunotoxins. Du X, et al. Blood, 2008 Jan 1. PMID 17895404, Free PMC Article
  3. A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis. Rivera NV, et al. Sci Rep, 2019 Dec 9. PMID 31819081, Free PMC Article
  4. FcRH1: an activation coreceptor on human B cells. Leu CM, et al. Blood, 2005 Feb 1. PMID 15479727
  5. FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2. DeLuca JM, et al. J Immunol, 2021 Dec 1. PMID 34697226, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FCRL1 immunoregulation in B cell development and malignancy.
    Title: FCRL1 immunoregulation in B cell development and malignancy.
  2. FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2.
    Title: FCRL1 Regulates B Cell Receptor-Induced ERK Activation through GRB2.
  3. Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.
    Title: Expression profile of Fc receptor-like molecules in patients with IgA nephropathy.
  4. A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
    Title: A Gene-Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis.
  5. FCRL1 gene expression down-regulates in both Hashimoto and Graves disease patients compared to normal subjects.
    Title: Expression Profile of Human Fc Receptor-Like 1, 2, and 4 Molecules in Peripheral Blood Mononuclear Cells of Patients with Hashimoto's Thyroiditis and Graves' Disease.
  6. Data show the Differences in high resolution melting analysis in promoters of tumor markers neuronal membrane glycoprotein M6-B, melanoma antigen family A12 and immunoglobulin superfamily Fc receptor indicated invasiveness of hepatocellular carcinoma.
    Title: Discovery and validation of DNA hypomethylation biomarkers for liver cancer using HRM-specific probes.
  7. Expression level of FCRL1 gene in peripheral blood B-lymphocytes is significantly higher in patients with autoimmune diseases.
    Title: [Expression of human B-cell specific receptor FCRL1 in normal individuals and in patients with autoimmune diseases].
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  10. Down-regulation of FCRL1 is associated with acute lymphoblastic leukemia.
    Title: Low representation of Fc receptor-like 1-5 molecules in leukemic cells from Iranian patients with acute lymphoblastic leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp667O1421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables coreceptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Fc receptor-like protein 1
Names
IFGP family protein 1
fc receptor homolog 1
fcR-like protein 1
hIFGP1
immune receptor translocation-associated protein 5
immunoglobulin superfamily Fc receptor, gp42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159397.2 → NP_001152869.1  Fc receptor-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001152869.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region compared to variant 1, that results in a frameshift. This variant encodes isoform 2, which is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK096690, AL356276, AL833674, DA939902
    Consensus CDS
    CCDS53382.1
    UniProtKB/Swiss-Prot
    Q96LA6
    Related
    ENSP00000351039.3, ENST00000358292.7
    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  2. NM_001159398.2 → NP_001152870.1  Fc receptor-like protein 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001152870.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AF329488, AL356276, AL833674, DA939902
    Consensus CDS
    CCDS53383.1
    UniProtKB/Swiss-Prot
    Q96LA6
    Related
    ENSP00000418130.1, ENST00000491942.1
    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  3. NM_052938.5 → NP_443170.1  Fc receptor-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_443170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL356276, AL833674, AY043464, DA939902
    Consensus CDS
    CCDS1170.1
    UniProtKB/Swiss-Prot
    B2RE05, Q8N759, Q8NDI0, Q96LA6, Q96PJ6
    Related
    ENSP00000357158.3, ENST00000368176.8
    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:19 → 90
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157794403..157820120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244869.4 → XP_005244926.1  Fc receptor-like protein 1 isoform X11

    Conserved Domains (2) summary
    smart00410
    Location:23 → 105
    IG_like; Immunoglobulin like
    pfam13927
    Location:111 → 184
    Ig_3; Immunoglobulin domain

  2. XM_011509134.3 → XP_011507436.1  Fc receptor-like protein 1 isoform X9

    See identical proteins and their annotated locations for XP_011507436.1

    Conserved Domains (3) summary
    smart00410
    Location:44 → 126
    IG_like; Immunoglobulin like
    pfam13895
    Location:40 → 126
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:132 → 205
    Ig_3; Immunoglobulin domain

  3. XM_011509127.3 → XP_011507429.1  Fc receptor-like protein 1 isoform X3

    Conserved Domains (3) summary
    smart00410
    Location:112 → 194
    IG_like; Immunoglobulin like
    pfam13895
    Location:108 → 194
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:200 → 273
    Ig_3; Immunoglobulin domain

  4. XM_011509135.3 → XP_011507437.1  Fc receptor-like protein 1 isoform X10

    Conserved Domains (2) summary
    smart00410
    Location:30 → 112
    IG_like; Immunoglobulin like
    pfam13927
    Location:118 → 191
    Ig_3; Immunoglobulin domain

  5. XM_011509133.3 → XP_011507435.1  Fc receptor-like protein 1 isoform X9

    See identical proteins and their annotated locations for XP_011507435.1

    Conserved Domains (3) summary
    smart00410
    Location:44 → 126
    IG_like; Immunoglobulin like
    pfam13895
    Location:40 → 126
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:132 → 205
    Ig_3; Immunoglobulin domain

  6. XM_005244867.3 → XP_005244924.1  Fc receptor-like protein 1 isoform X8

    Related
    ENST00000489998.5
    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  7. XM_011509130.2 → XP_011507432.1  Fc receptor-like protein 1 isoform X7

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  8. XM_005244866.3 → XP_005244923.1  Fc receptor-like protein 1 isoform X6

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  9. XM_011509129.2 → XP_011507431.1  Fc receptor-like protein 1 isoform X5

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  10. XM_011509128.2 → XP_011507430.1  Fc receptor-like protein 1 isoform X4

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  11. XM_011509126.2 → XP_011507428.1  Fc receptor-like protein 1 isoform X2

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  12. XM_011509125.2 → XP_011507427.1  Fc receptor-like protein 1 isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

  13. XM_047444001.1 → XP_047299957.1  Fc receptor-like protein 1 isoform X13

  14. XM_011509136.2 → XP_011507438.1  Fc receptor-like protein 1 isoform X12

    Conserved Domains (3) summary
    smart00410
    Location:119 → 201
    IG_like; Immunoglobulin like
    pfam13895
    Location:115 → 201
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:207 → 280
    Ig_3; Immunoglobulin domain

RNA

  1. XR_921738.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156931472..156957188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054334157.1 → XP_054190132.1  Fc receptor-like protein 1 isoform X11

  2. XM_054334155.1 → XP_054190130.1  Fc receptor-like protein 1 isoform X9

  3. XM_054334148.1 → XP_054190123.1  Fc receptor-like protein 1 isoform X3

  4. XM_054334156.1 → XP_054190131.1  Fc receptor-like protein 1 isoform X10

  5. XM_054334154.1 → XP_054190129.1  Fc receptor-like protein 1 isoform X9

  6. XM_054334153.1 → XP_054190128.1  Fc receptor-like protein 1 isoform X8

  7. XM_054334152.1 → XP_054190127.1  Fc receptor-like protein 1 isoform X7

  8. XM_054334151.1 → XP_054190126.1  Fc receptor-like protein 1 isoform X6

  9. XM_054334150.1 → XP_054190125.1  Fc receptor-like protein 1 isoform X5

  10. XM_054334149.1 → XP_054190124.1  Fc receptor-like protein 1 isoform X4

  11. XM_054334147.1 → XP_054190122.1  Fc receptor-like protein 1 isoform X2

  12. XM_054334146.1 → XP_054190121.1  Fc receptor-like protein 1 isoform X1

  13. XM_054334159.1 → XP_054190134.1  Fc receptor-like protein 1 isoform X13

  14. XM_054334158.1 → XP_054190133.1  Fc receptor-like protein 1 isoform X12

RNA

  1. XR_008485907.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LA6.1 GenPept UniProtKB/Swiss-Prot:Q96LA6

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