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LDLR-AS1 LDLR antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 115271120, updated on 10-Oct-2023

Summary

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Official Symbol
LDLR-AS1provided by HGNC
Official Full Name
LDLR antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:54407
See related
AllianceGenome:HGNC:54407
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene represents a regulatory lncRNA that overlaps the 5' UTR and coding sequence of the LDLR (low density lipoprotein receptor) gene. This lncRNA overlaps LDLR in the antisense orientation, and has been shown to downregulate production of the low density lipoprotein receptor. [provided by RefSeq, Jul 2019]
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Genomic context

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Location:
19p13.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (11089068..11089659, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (11216065..11216656, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (11199744..11200335, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10095 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10096 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:11046750-11047081 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:11048011-11048510 Neighboring gene translocase of inner mitochondrial membrane 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10097 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10099 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14001 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11087822-11088514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11120526-11121026 Neighboring gene RNA, 7SL, cytoplasmic 192, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11138820-11139320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14002 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11167289-11167788 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200393-11200988 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11200989-11201582 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr19:11202176-11203375 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:11205098-11206297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:11212882-11213520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:11215560-11216060 Neighboring gene low density lipoprotein receptor Neighboring gene microRNA 6886 Neighboring gene VISTA enhancer hs1754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10101 Neighboring gene SPC24 component of NDC80 kinetochore complex

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of LDL Uptake in Human Cells by Targeting the LDLR Regulatory Long Non-coding RNA BM450697. Ray RM, et al. Mol Ther Nucleic Acids, 2019 Sep 6. PMID 31279228, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • lncRNA BM450697

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_163945.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC011485

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    11089068..11089659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    11216065..11216656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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