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CKB creatine kinase B [ Homo sapiens (human) ]

Gene ID: 1152, updated on 7-Apr-2024

Summary

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Official Symbol
CKBprovided by HGNC
Official Full Name
creatine kinase Bprovided by HGNC
Primary source
HGNC:HGNC:1991
See related
Ensembl:ENSG00000166165 MIM:123280; AllianceGenome:HGNC:1991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29
Summary
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues See more
Orthologs
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Genomic context

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See CKB in Genome Data Viewer
Location:
14q32.33
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103519667..103522830, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97755711..97758874, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103986004..103989167, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9104 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103921390-103921890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103921891-103922391 Neighboring gene uncharacterized LOC112268130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103984081-103984968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103986745-103987632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6155 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103989409-103990294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103999205-103999704 Neighboring gene uncharacterized LOC124903392 Neighboring gene tRNA methyltransferase 61A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104008443-104009162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104009885-104010606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9105 Neighboring gene RNA, U7 small nuclear 160 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation. Wang Z, et al. Neoplasia, 2021 Nov. PMID 34706306, Free PMC Article
  2. Creatine kinase in human erythrocytes: A genetic anomaly reveals presence of soluble brain-type isoform. Kay L, et al. Blood Cells Mol Dis, 2017 May. PMID 28364583
  3. Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites. Schlattner U, et al. Amino Acids, 2016 Aug. PMID 27318991
  4. Serum brain-type creatine kinase increases in children with osteogenesis imperfecta during neridronate treatment. D'Eufemia P, et al. Pediatr Res, 2014 May. PMID 24518563
  5. Effect of SNPs on creatine kinase structure and function: identifying potential molecular mechanisms for possible creatine kinase deficiency diseases. Li C, et al. PLoS One, 2012. PMID 23049898, Free PMC Article

See all (205) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
    Title: Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function.
  2. CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.
    Title: CKB inhibits epithelial-mesenchymal transition and prostate cancer progression by sequestering and inhibiting AKT activation.
  3. Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer.
    Title: Clinical impact of creatine phosphokinase and c-reactive protein as predictors of postgastrectomy complications in patients with gastric cancer.
  4. Creatine kinase B controls futile creatine cycling in thermogenic fat.
    Title: Creatine kinase B controls futile creatine cycling in thermogenic fat.
  5. The data revealed a varying but significant increase of CK activity in CKBE individuals as compared to controls, reaching an almost 800-fold increase in two CKBE individuals which also had increased erythrocyte creatine.
    Title: Creatine kinase in human erythrocytes: A genetic anomaly reveals presence of soluble brain-type isoform.
  6. Association and oligomerization of Prx II could take part in recovery and protection of the CK BB enzyme activity from inactivation during heat-induced stress.
    Title: Prx II and CKBB proteins interaction under physiologic al and thermal stress conditions in A549 and HeLa cells.
  7. membrane localization of BCK seems to be an important and regulated feature for the fueling of membrane-located, ATP-dependent processes, stressing again the importance of local rather than global ATP concentrations.
    Title: Cellular compartmentation of energy metabolism: creatine kinase microcompartments and recruitment of B-type creatine kinase to specific subcellular sites.
  8. These findings support increased CK activity as protection against ischaemia-reperfusion injury, in particular, protection via CKMT2 in a cardiac-relevant cell line, which merits further investigation in vivo.
    Title: Increasing creatine kinase activity protects against hypoxia / reoxygenation injury but not against anthracycline toxicity in vitro.
  9. SRC, LYN and CKB expression or DNA methylation could be useful markers for predicting tumor progression.
    Title: Deregulated Expression of SRC, LYN and CKB Kinases by DNA Methylation and Its Potential Role in Gastric Cancer Invasiveness and Metastasis.
  10. CK-MB levels were higher after ERCP in non-ischemic patients compared with a myocardial ischemia group. Creatine phosphokinase levels did not differ significantly between groups.
    Title: Role of serum myeloperoxidase, CPK, CK-MB, and cTnI tests in early diagnosis of myocardial ischemia during ERCP.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables creatine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables creatine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in futile creatine cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphocreatine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
creatine kinase B-type
Names
brain creatine kinase
creatine kinase B chain
creatine kinase brain
creatine kinase brain-type
creatine phosphokinase B-type
epididymis luminal protein 211
epididymis secretory protein Li 29
NP_001349460.1
NP_001814.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362531.2 → NP_001349460.1  creatine kinase B-type isoform 2

    Status: REVIEWED

    Source sequence(s)
    BM684665, BP213119, KU177978
    Consensus CDS
    CCDS91943.1
    UniProtKB/TrEMBL
    A0A0S2Z471, V9HW77
    Related
    ENSP00000508488.1, ENST00000689346.1
    Conserved Domains (1) summary
    cd00716
    Location:16 → 397
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

  2. NM_001823.5 → NP_001814.2  creatine kinase B-type isoform 1

    See identical proteins and their annotated locations for NP_001814.2

    Status: REVIEWED

    Source sequence(s)
    AK312282, BM684665, BP213119
    Consensus CDS
    CCDS9981.1
    UniProtKB/Swiss-Prot
    A8K236, B2R5R4, P12277, Q2LE07, Q6FG40, Q9UC66
    UniProtKB/TrEMBL
    V9HW77, V9HWH2
    Related
    ENSP00000299198.2, ENST00000348956.7
    Conserved Domains (1) summary
    cd00716
    Location:16 → 373
    creatine_kinase_like; Phosphagen (guanidino) kinases such as creatine kinase and similar enzymes

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    103519667..103522830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    97755711..97758874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12277.1 GenPept UniProtKB/Swiss-Prot:P12277

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