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c5 complement component 5 [ Salmo trutta (river trout) ]

Gene ID: 115167684, updated on 17-Mar-2024

Summary

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Gene symbol
c5
Gene description
complement component 5
See related
Ensembl:ENSSTUG00000038463
Gene type
protein coding
RefSeq status
MODEL
Organism
Salmo trutta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Salmo
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 29
Exon count:
41
Annotation release Status Assembly Chr Location
100 current fSalTru1.1 (GCF_901001165.1) 29 NC_042985.1 (44694185..44752710, complement)

Chromosome 29 - NC_042985.1Genomic Context describing neighboring genes Neighboring gene ras-related protein Rab-14-like Neighboring gene uncharacterized LOC115167683 Neighboring gene PR domain containing 12b Neighboring gene far upstream element-binding protein 3-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_042985.1 Chromosome 29 Reference fSalTru1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Salmo trutta Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fSalTru1.1 Primary Assembly

Genomic

  1. NC_042985.1 Reference fSalTru1.1 Primary Assembly

    Range
    44694185..44752710 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029722326.1 → XP_029578186.1  complement C5 isoform X2

    UniProtKB/TrEMBL
    A0A674CVF2, A0A674CVS2
    Related
    ENSSTUP00000087423.1, ENSSTUT00000093046.1
    Conserved Domains (10) summary
    cd00017
    Location:690 → 757
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    cd02896
    Location:1008 → 1315
    complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...
    pfam00207
    Location:779 → 871
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1433 → 1523
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:352 → 461
    MG4; Macroglobulin domain MG4
    pfam17790
    Location:20 → 119
    MG1; Macroglobulin domain MG1
    pfam17791
    Location:221 → 301
    MG3; Macroglobulin domain MG3
    pfam01835
    Location:125 → 219
    A2M_N; MG2 domain
    pfam07703
    Location:471 → 616
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:1542 → 1692
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

  2. XM_029722325.1 → XP_029578185.1  complement C5 isoform X1

    UniProtKB/TrEMBL
    A0A674CVS2
    Conserved Domains (10) summary
    cd00017
    Location:690 → 757
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam00207
    Location:779 → 871
    A2M; Alpha-2-macroglobulin family
    pfam07677
    Location:1459 → 1549
    A2M_recep; A-macroglobulin receptor
    pfam17789
    Location:352 → 461
    MG4; Macroglobulin domain MG4
    pfam17790
    Location:20 → 119
    MG1; Macroglobulin domain MG1
    pfam17791
    Location:221 → 301
    MG3; Macroglobulin domain MG3
    pfam01835
    Location:125 → 219
    A2M_N; MG2 domain
    pfam07703
    Location:471 → 616
    A2M_N_2; Alpha-2-macroglobulin family N-terminal region
    cl02512
    Location:1568 → 1718
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...
    cl08267
    Location:1008 → 1341
    ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
Nucleotide Protein
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