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cbl Cbl proto-oncogene [ Salmo trutta (river trout) ]

Gene ID: 115162940, updated on 21-Dec-2023

Summary

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Gene symbol
cbl
Gene description
Cbl proto-oncogene
See related
Ensembl:ENSSTUG00000005294
Gene type
protein coding
RefSeq status
MODEL
Organism
Salmo trutta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Salmo
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Genomic context

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See cbl in Genome Data Viewer
Location:
chromosome: 26
Exon count:
16
Annotation release Status Assembly Chr Location
100 current fSalTru1.1 (GCF_901001165.1) 26 NC_042982.1 (5308069..5361983)

Chromosome 26 - NC_042982.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor ionotropic, kainate 4-like Neighboring gene U7 small nuclear RNA Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene cell surface glycoprotein MUC18-like Neighboring gene E3 ubiquitin-protein ligase RNF26-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_042982.1 Chromosome 26 Reference fSalTru1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Salmo trutta Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fSalTru1.1 Primary Assembly

Genomic

  1. NC_042982.1 Reference fSalTru1.1 Primary Assembly

    Range
    5308069..5361983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029714473.1 → XP_029570333.1  E3 ubiquitin-protein ligase CBL isoform X1

    UniProtKB/TrEMBL
    A0A673WHC2
    Related
    ENSSTUP00000011345.1, ENSSTUT00000012039.1
    Conserved Domains (6) summary
    cd09920
    Location:239 → 335
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PHA03247
    Location:464 → 882
    PHA03247; large tegument protein UL36; Provisional
    cd14393
    Location:883 → 922
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:345 → 410
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:37 → 155
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:162 → 245
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_029714474.1 → XP_029570334.1  E3 ubiquitin-protein ligase CBL isoform X2

    UniProtKB/TrEMBL
    A0A673WHC2, A0A673WRN4
    Related
    ENSSTUP00000011297.1, ENSSTUT00000011983.1
    Conserved Domains (6) summary
    cd09920
    Location:239 → 335
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    PHA03247
    Location:464 → 873
    PHA03247; large tegument protein UL36; Provisional
    cd14393
    Location:874 → 913
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:345 → 410
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:37 → 155
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:162 → 245
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
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