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syk spleen tyrosine kinase [ Salmo trutta (river trout) ]

Gene ID: 115160112, updated on 11-Apr-2024

Summary

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Gene symbol
syk
Gene description
spleen tyrosine kinase
See related
Ensembl:ENSSTUG00000025230
Gene type
protein coding
RefSeq status
MODEL
Organism
Salmo trutta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Salmo
Orthologs
human zebrafish all
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Genomic context

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See syk in Genome Data Viewer
Location:
chromosome: 23
Exon count:
14
Annotation release Status Assembly Chr Location
100 current fSalTru1.1 (GCF_901001165.1) 23 NC_042979.1 (43158011..43189725)

Chromosome 23 - NC_042979.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC115160111 Neighboring gene PDZ and pleckstrin homology domains 1 Neighboring gene DIRAS family GTPase 2 Neighboring gene uncharacterized LOC115160116 Neighboring gene AU RNA binding protein/enoyl-CoA hydratase Neighboring gene nuclear factor, interleukin 3 regulated

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_042979.1 Chromosome 23 Reference fSalTru1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables non-membrane spanning protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neutrophil activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of alpha-beta T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell adhesion mediated by integrin IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of mast cell degranulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of platelet aggregation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase SYK
Names
spleen associated tyrosine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Salmo trutta Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fSalTru1.1 Primary Assembly

Genomic

  1. NC_042979.1 Reference fSalTru1.1 Primary Assembly

    Range
    43158011..43189725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029710446.1 → XP_029566306.1  tyrosine-protein kinase SYK isoform X1

    UniProtKB/TrEMBL
    A0A674AIG9
    Related
    ENSSTUP00000058865.1, ENSSTUT00000061852.1

  2. XM_029710448.1 → XP_029566308.1  tyrosine-protein kinase SYK isoform X3

    UniProtKB/TrEMBL
    A0A674AKE9
    Related
    ENSSTUP00000058836.1, ENSSTUT00000061823.1

  3. XM_029710447.1 → XP_029566307.1  tyrosine-protein kinase SYK isoform X2

    UniProtKB/TrEMBL
    A0A674AIG9, A0A674AKJ3
    Related
    ENSSTUP00000058881.1, ENSSTUT00000061869.1
    Conserved Domains (3) summary
    cd05116
    Location:357 → 613
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:8 → 111
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cl15255
    Location:159 → 257
    SH2; Src homology 2 (SH2) domain

  4. XM_029710449.1 → XP_029566309.1  tyrosine-protein kinase SYK isoform X4

    UniProtKB/TrEMBL
    A0A674AHR3, A0A674AKE9
    Related
    ENSSTUP00000058813.1, ENSSTUT00000061799.1
    Conserved Domains (3) summary
    cd05116
    Location:333 → 589
    PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase
    cd09938
    Location:8 → 111
    SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins
    cl15255
    Location:159 → 257
    SH2; Src homology 2 (SH2) domain
Nucleotide Protein
Heading Accession and Version

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