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Adam5 a disintegrin and metallopeptidase domain 5 [ Mus musculus (house mouse) ]

Gene ID: 11499, updated on 2-Nov-2024

Summary

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Official Symbol
Adam5provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 5provided by MGI
Primary source
MGI:MGI:104730
See related
Ensembl:ENSMUSG00000031554 AllianceGenome:MGI:104730
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tMDCII; tMDC II
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. This gene is located in a cluster of related ADAM genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Restricted expression toward testis adult (RPKM 104.0) See more
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Genomic context

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See Adam5 in Genome Data Viewer
Location:
8 A2; 8 13.26 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (25217109..25314385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (24727093..24824369, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 18 Neighboring gene predicted gene, 51566 Neighboring gene predicted gene, 26208 Neighboring gene ADAM metallopeptidase domain 3 Neighboring gene STARR-seq mESC enhancer starr_20948 Neighboring gene a disintegrin and metallopeptidase domain 32 Neighboring gene STARR-seq mESC enhancer starr_20951 Neighboring gene STARR-seq mESC enhancer starr_20952 Neighboring gene ADAM metallopeptidase domain 9 Neighboring gene STARR-positive B cell enhancer mm9_chr8:26127373-26127674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tex101 is essential for male fertility by affecting sperm migration into the oviduct in mice. Li W, et al. J Mol Cell Biol, 2013 Oct. PMID 23969891
  2. Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. Ballock RT, et al. J Cell Physiol, 1994 May. PMID 8163572
  3. Expression and relationship of male reproductive ADAMs in mouse. Kim T, et al. Biol Reprod, 2006 Apr. PMID 16407499
  4. ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain. Wolfsberg TG, et al. Dev Biol, 1995 May. PMID 7750654
  5. A family of cellular proteins related to snake venom disintegrins. Weskamp G, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146185, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 5
Names
a disintegrin and metalloprotease domain (ADAM) 5
transmembrane metalloproteinase-like, disintegrin-like, and cysteine-rich protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272057.1 → NP_001258986.1  disintegrin and metalloproteinase domain-containing protein 5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001258986.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons and contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AK161262, BC094237
    Consensus CDS
    CCDS85515.1
    UniProtKB/TrEMBL
    F6S1B5
    Related
    ENSMUSP00000147290.2, ENSMUST00000209935.2
    Conserved Domains (5) summary
    smart00050
    Location:397 → 473
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:475 → 618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:185 → 376
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:185 → 378
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:35 → 141
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001272058.1 → NP_001258987.1  disintegrin and metalloproteinase domain-containing protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001258987.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AK016574, AK161262, AK161415
    Consensus CDS
    CCDS72107.1
    UniProtKB/Swiss-Prot
    Q3TTE0
    Related
    ENSMUSP00000052661.8, ENSMUST00000050300.15
    Conserved Domains (5) summary
    smart00050
    Location:397 → 473
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:475 → 618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:185 → 376
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:185 → 378
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:35 → 141
    Pep_M12B_propep; Reprolysin family propeptide

  3. NM_001272059.1 → NP_001258988.1  disintegrin and metalloproteinase domain-containing protein 5 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1. This isoform (4) may undergo proteolytic processing similar to isoform 3.
    Source sequence(s)
    AK161262, AK161415
    UniProtKB/TrEMBL
    F6S1B5
    Related
    ENSMUSP00000121272.2, ENSMUST00000132180.8
    Conserved Domains (5) summary
    smart00050
    Location:397 → 473
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:475 → 618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:185 → 376
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:185 → 378
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:35 → 141
    Pep_M12B_propep; Reprolysin family propeptide

  4. NM_007401.3 → NP_031427.2  disintegrin and metalloproteinase domain-containing protein 5 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_031427.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK161262, BC094237
    Consensus CDS
    CCDS52525.1
    UniProtKB/Swiss-Prot
    Q3TTE0, Q3TTE2, Q52KQ5, Q60623, Q60816, Q8CDV5, Q9D4F0
    Related
    ENSMUSP00000112422.2, ENSMUST00000118419.2
    Conserved Domains (5) summary
    smart00050
    Location:397 → 473
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:475 → 618
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:185 → 376
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:185 → 378
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:35 → 141
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    25217109..25314385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242115.1 → XP_011240417.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_011240417.1

    UniProtKB/TrEMBL
    F6S1B5
    Conserved Domains (4) summary
    smart00050
    Location:397 → 473
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:475 → 618
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:185 → 378
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:37 → 142
    Pep_M12B_propep; Reprolysin family propeptide

  2. XM_006508985.2 → XP_006509048.1  disintegrin and metalloproteinase domain-containing protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006509048.1

    UniProtKB/TrEMBL
    F6S1B5
    Conserved Domains (4) summary
    smart00050
    Location:397 → 473
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:475 → 618
    ACR; ADAM Cysteine-Rich Domain
    pfam01421
    Location:185 → 378
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:37 → 142
    Pep_M12B_propep; Reprolysin family propeptide
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TTE0.1 GenPept UniProtKB/Swiss-Prot:Q3TTE0

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