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EPB41L4A-AS1 EPB41L4A antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 114915, updated on 10-Oct-2023

Summary

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Official Symbol
EPB41L4A-AS1provided by HGNC
Official Full Name
EPB41L4A antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:30749
See related
AllianceGenome:HGNC:30749
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIGA1; C5orf26; NCRNA00219
Expression
Ubiquitous expression in ovary (RPKM 35.5), endometrium (RPKM 12.6) and 25 other tissues See more
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Genomic context

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Location:
5q22.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (112160526..112162501)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (112670980..112672955)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (111496223..111498198)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene neuronal regeneration related protein Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 14 Neighboring gene NREP antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111326855-111327356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111327357-111327856 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111333199-111334398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22904 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:111496090-111497289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:111501161-111501838 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:111501839-111502516 Neighboring gene erythrocyte membrane protein band 4.1 like 4A Neighboring gene uncharacterized LOC124901044 Neighboring gene small nucleolar RNA, H/ACA box 13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:111553293-111553794 Neighboring gene uncharacterized LOC101927023 Neighboring gene NANOG hESC enhancer GRCh37_chr5:111573109-111573620

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56(bright) NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis. Chai W, et al. Clin Immunol, 2023 May. PMID 37024023
  2. IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis. Dong B, et al. Crit Rev Eukaryot Gene Expr, 2023. PMID 36734855
  3. LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer. Yang F, et al. Ann Clin Lab Sci, 2022 Jan. PMID 35181612
  4. Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer. Bin J, et al. J Cell Physiol, 2021 Jan. PMID 32557646
  5. LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2. Liao M, et al. EBioMedicine, 2019 Mar. PMID 30796006, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56[bright] NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis.
    Title: Elevated exosome-transferrable lncRNA EPB41L4A-AS1 in CD56(bright) NK cells is responsible for the impaired NK function in neuroblastoma patients by suppressing cell glycolysis.
  2. IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis.
    Title: IncRNA EPB41L4A-AS1 Mitigates the Proliferation of Non-Small-Cell Lung Cancer Cells through the miR-105-5p/GIMAP6 Axis.
  3. LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer.
    Title: LncRNA EPB41L4A-AS1 Regulates Cell Proliferation, Apoptosis and Metastasis in Breast Cancer.
  4. Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
    Title: Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
  5. miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells.
    Title: miR-146a interacting with lncRNA EPB41L4A-AS1 and lncRNA SNHG7 inhibits proliferation of bone marrow-derived mesenchymal stem cells.
  6. EPB41L4A-AS1 functions as a repressor of the Warburg effect by mediating nucleolar translocation of HDAC2.
    Title: LncRNA EPB41L4A-AS1 regulates glycolysis and glutaminolysis by mediating nucleolar translocation of HDAC2.
  7. vascular calcification-associated factor (VCAF) is present in human calcified arteries but not noncalcified arteries
    Title: Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • EPB41L4A antisense RNA 1 (non-protein coding)
  • transcript induced by growth arrest 1

Clone Names

  • MGC126893, MGC138282

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015370.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB048207, DA266578

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    112160526..112162501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    112670980..112672955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_053000.1: Suppressed sequence

    Description
    NM_053000.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and currently there is no support for the protein.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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