Zmynd10 zinc finger, MYND domain containing 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zmynd10provided by MGI
Official Full Name: zinc finger, MYND domain containing 10provided by MGI
Primary source: MGI:MGI:2387863
See related: Ensembl:ENSMUSG00000010044 AllianceGenome:MGI:2387863
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Blu
Summary: Enables molecular adaptor activity and protein folding chaperone. Involved in inner dynein arm assembly; outer dynein arm assembly; and positive regulation of motile cilium assembly. Acts upstream of or within several processes, including motile cilium assembly; protein folding; and protein localization to cilium. Located in apical plasma membrane and cytoplasm. Is expressed in lung; nasal cavity epithelium; and testis. Used to study primary ciliary dyskinesia 22. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 22. Orthologous to human ZMYND10 (zinc finger MYND-type containing 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 56.3) and kidney adult (RPKM 6.2) See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 58.12 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107424067..107428520)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (107546872..107551321)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZMYND10 is a novel co-chaperone that confers specificity for the FKBP8-HSP90 chaperone complex towards axonemal dynein clients required for cilia motility.
Title: ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
results demonstrated that ZMYND10 regulated the early stage of DA cytoplasmic pre-assembly by stabilizing DNAI1
Title: ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms.
Zmynd10 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cilium movement	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inner dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in inner dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in motile cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in outer dynein arm assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within outer dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in outer dynein arm assembly	ISO Inferred from Sequence Orthology more info
involved_in outer dynein arm assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein folding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to cilium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in centriolar satellite	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dynein axonemal particle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger MYND domain-containing protein 10

Names: protein BLu

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379079.1 → NP_001366008.1 zinc finger MYND domain-containing protein 10 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variant 4, encodes isoform 3.

Source sequence(s)

AL672219

Conserved Domains (1) summary

pfam01753
Location:351 → 387

zf-MYND; MYND finger
NM_001379080.1 → NP_001366009.1 zinc finger MYND domain-containing protein 10 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4), as well as variant 3, encodes isoform 3.

Source sequence(s)

AL672219

Conserved Domains (1) summary

pfam01753
Location:351 → 387

zf-MYND; MYND finger
NM_001404947.1 → NP_001391876.1 zinc finger MYND domain-containing protein 10 isoform 5

Status: VALIDATED

Source sequence(s)

AL672219
NM_053253.4 → NP_444483.2 zinc finger MYND domain-containing protein 10 isoform 1

See identical proteins and their annotated locations for NP_444483.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL672219, BC052357, BY284492

Consensus CDS

CCDS23493.1

UniProtKB/Swiss-Prot

Q3V1P0, Q80W73, Q99ML0

Related

ENSMUSP00000010188.8, ENSMUST00000010188.9

Conserved Domains (1) summary

pfam01753
Location:394 → 430

zf-MYND; MYND finger

RNA

NR_166465.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL672219

Related

ENSMUST00000193303.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107424067..107428520

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511630.4 → XP_006511693.1 zinc finger MYND domain-containing protein 10 isoform X1

Conserved Domains (1) summary

pfam01753
Location:432 → 468

zf-MYND; MYND finger