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zp2.6 zona pellucida glycoprotein 2, tandem duplicate 6 [ Danio rerio (zebrafish) ]

Gene ID: 114440, updated on 2-Nov-2024

Summary

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Official Symbol
zp2.6provided by ZNC
Official Full Name
zona pellucida glycoprotein 2, tandem duplicate 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-090306-2
See related
Ensembl:ENSDARG00000091409 AllianceGenome:ZFIN:ZDB-GENE-090306-2
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zp2; zp2c; zp2.4; fc33d01; zgc:111913; zgc:111918
Summary
Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Is expressed in ovary. Orthologous to several human genes including ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zp2.6 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54304800..54306651)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54435228..54436906)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 3 Neighboring gene si:zfos-1505d6.3 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 1 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of housekeeping genes suitable for gene expression analysis in the zebrafish. Casadei R, et al. Gene Expr Patterns, 2011 Mar-Apr. PMID 21281742
  2. Regulation of zebrafish zona pellucida gene activity in developing oocytes. Mold DE, et al. Biol Reprod, 2009 Jul. PMID 19299318
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC63627, MGC111913

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prevention of polyspermy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zona pellucida glycoprotein 2, tandem duplicate 6
Names
zona pellucida glycoprotein 2, tandem duplicate 4
zona pellucida glycoprotein 2.4
zona pellucida glycoprotein 2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131829.2 → NP_571904.2  zona pellucida glycoprotein 2, tandem duplicate 6 precursor

    Status: VALIDATED

    Source sequence(s)
    CU914156
    UniProtKB/TrEMBL
    A0A8M1PCA2, F1QJ26
    Related
    ENSDARP00000109385.2, ENSDART00000121661.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    54304800..54306651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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