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zp2.2 zona pellucida glycoprotein 2, tandem duplicate 2 [ Danio rerio (zebrafish) ]

Gene ID: 114438, updated on 2-Nov-2024

Summary

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Official Symbol
zp2.2provided by ZNC
Official Full Name
zona pellucida glycoprotein 2, tandem duplicate 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-010622-1
See related
Ensembl:ENSDARG00000105346 AllianceGenome:ZFIN:ZDB-GENE-010622-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zp2; zp2a; fj99c12; wu:fj99c12
Summary
Predicted to enable acrosin binding activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in binding activity of sperm to zona pellucida and prevention of polyspermy. Predicted to act upstream of or within single fertilization. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and egg coat. Is expressed in ovary. Orthologous to several human genes including ZP4 (zona pellucida glycoprotein 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See zp2.2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (54290361..54292144)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (54420790..54422573)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase 3 Neighboring gene actin related protein 10 Neighboring gene si:zfos-1505d6.3 Neighboring gene zona pellucida glycoprotein 2, tandem duplicate 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution and nomenclature of the zona pellucida gene family. Spargo SC, et al. Biol Reprod, 2003 Feb. PMID 12533396
  2. Regulation of zebrafish zona pellucida gene activity in developing oocytes. Mold DE, et al. Biol Reprod, 2009 Jul. PMID 19299318
  3. Transcriptomic Analysis for Differentially Expressed Genes in Ovarian Follicle Activation in the Zebrafish. Zhu B, et al. Front Endocrinol (Lausanne), 2018. PMID 30364302, Free PMC Article
  4. Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells. Biava PM, et al. Curr Pharm Biotechnol, 2015. PMID 26201607, Free PMC Article
  5. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC158204

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acrosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in prevention of polyspermy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in egg coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zona pellucida sperm-binding protein 2.2
Names
zona pellucida glycoprotein 2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131827.1 → NP_571902.1  zona pellucida sperm-binding protein 2.2 precursor

    See identical proteins and their annotated locations for NP_571902.1

    Status: PROVISIONAL

    Source sequence(s)
    AF331968
    UniProtKB/TrEMBL
    Q98SS0
    Related
    ENSDARP00000142252.1, ENSDART00000173347.2
    Conserved Domains (3) summary
    smart00018
    Location:81 → 121
    PD; P or trefoil or TFF domain
    smart00241
    Location:143 → 406
    ZP; Zona pellucida (ZP) domain
    pfam00100
    Location:270 → 404
    Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    54290361..54292144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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