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Asah2 N-acylsphingosine amidohydrolase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114104, updated on 2-Nov-2024

Summary

Official Symbol
Asah2provided by RGD
Official Full Name
N-acylsphingosine amidohydrolase 2provided by RGD
Primary source
RGD:69410
See related
EnsemblRapid:ENSRNOG00000012196 AllianceGenome:RGD:69410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables N-acylsphingosine amidohydrolase activity. Involved in ceramide biosynthetic process; ceramide catabolic process; and sphingosine biosynthetic process. Located in several cellular components, including extracellular space; membrane raft; and mitochondrion. Orthologous to human ASAH2 (N-acylsphingosine amidohydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 32.8), Adrenal (RPKM 25.4) and 9 other tissues See more
Orthologs
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Genomic context

See Asah2 in Genome Data Viewer
Location:
1q52
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (239278994..239386598, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (229865662..229973253, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (250557042..250665083, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein kinase cGMP-dependent 1 Neighboring gene uncharacterized LOC120097454 Neighboring gene APOBEC1 complementation factor Neighboring gene sphingomyelin synthase 1 Neighboring gene small nucleolar RNA SNORA48

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acylsphingosine amidohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-acylsphingosine amidohydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables N-acylsphingosine amidohydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables N-acylsphingosine amidohydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables N-acylsphingosine amidohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ceramide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ceramide catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ceramide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ceramide metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lipid digestion ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid digestion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sphingosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sphingosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sphingosine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutral ceramidase
Names
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2
NCDase
acylsphingosine deacylase 2
neutral/alkaline ceramidase
NP_446098.1
XP_006231325.1
XP_006231332.1
XP_008758542.1
XP_017444136.1
XP_017444137.1
XP_017444139.1
XP_038962801.1
XP_038962806.1
XP_038962807.1
XP_038962839.1
XP_038962916.1
XP_038962949.1
XP_038962978.1
XP_038963012.1
XP_038963044.1
XP_038963081.1
XP_063118252.1
XP_063118305.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053646.2NP_446098.1  neutral ceramidase

    See identical proteins and their annotated locations for NP_446098.1

    Status: VALIDATED

    Source sequence(s)
    AB057433, JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Related
    ENSRNOP00000073116.2, ENSRNOT00000077135.3
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    239278994..239386598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107021.2XP_038962949.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  2. XM_039106988.2XP_038962916.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  3. XM_006231263.3XP_006231325.1  neutral ceramidase isoform X1

    See identical proteins and their annotated locations for XP_006231325.1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  4. XM_006231270.3XP_006231332.1  neutral ceramidase isoform X1

    See identical proteins and their annotated locations for XP_006231332.1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  5. XM_063262182.1XP_063118252.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A6I102
  6. XM_008760320.4XP_008758542.1  neutral ceramidase isoform X1

    See identical proteins and their annotated locations for XP_008758542.1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  7. XM_039107153.2XP_038963081.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  8. XM_039106879.2XP_038962807.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  9. XM_039107084.2XP_038963012.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  10. XM_063262235.1XP_063118305.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A6I102
  11. XM_039107050.2XP_038962978.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Related
    ENSRNOP00000104976.1, ENSRNOT00000128918.1
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  12. XM_039107116.2XP_038963044.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  13. XM_017588650.3XP_017444139.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  14. XM_039106911.2XP_038962839.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  15. XM_039106878.2XP_038962806.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  16. XM_017588648.3XP_017444137.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  17. XM_039106873.2XP_038962801.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal
  18. XM_017588647.3XP_017444136.1  neutral ceramidase isoform X1

    UniProtKB/Swiss-Prot
    Q91XT9
    UniProtKB/TrEMBL
    A0A8L2Q853, A6I102
    Conserved Domains (2) summary
    pfam04734
    Location:83589
    Ceramidase_alk; Neutral/alkaline non-lysosomal ceramidase, N-terminal
    pfam17048
    Location:591758
    Ceramidse_alk_C; Neutral/alkaline non-lysosomal ceramidase, C-terminal