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LOC113788263 H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899 [ Homo sapiens (human) ]

Gene ID: 113788263, updated on 10-Oct-2023

Summary

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Gene symbol
LOC113788263
Gene description
H3K27ac-H3K4me1 hESC enhancers GRCh37_chr8:142036197-142037048 and GRCh37_chr8:142037049-142037899
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. Two subregions marked by the H3K27ac and H3K4me1 histone modifications were validated as active enhancers by ChIP-STARR-seq in naive human embryonic stem cells. An overlapping subregion was also validated as a functional enhancer by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating DNase unmatched - State 5:Enh, candidate strong enhancer, open chromatin). [provided by RefSeq, Oct 2022]
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Genomic context

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See LOC113788263 in Genome Data Viewer
Location:
8q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (141026098..141027800)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (142146197..142147900)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (142036869..142037163)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151a Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:141901324-141901954 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:141901955-141902583 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141903275-141903488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141959143-141960131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28038 Neighboring gene RNA, 5S ribosomal pseudogene 278 Neighboring gene Sharpr-MPRA regulatory region 10587 Neighboring gene NANOG hESC enhancer GRCh37_chr8:141986399-141986923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142026737-142027298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142030905-142031616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142032328-142033038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142033039-142033749 Neighboring gene uncharacterized LOC105375783 Neighboring gene uncharacterized LOC124902030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047320-142047944 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142047945-142048570 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142048571-142049195 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:142051549-142052338 Neighboring gene uncharacterized LOC105375784 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142069799-142070496

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

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Other Names

  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142036197-142037048
  • H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:142037049-142037899
  • Sharpr-MPRA regulatory region 11335

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_062556.2 

    Range
    101..1803
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    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    141026098..141027800
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    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    142146197..142147900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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